Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies

JD Roth, BL Roland, RL Cole… - Proceedings of the …, 2008 - National Acad Sciences
Body weight is regulated by complex neurohormonal interactions between endocrine signals
of long-term adiposity (eg, leptin, a hypothalamic signal) and short-term satiety (eg, amylin, …

Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum

RL Cole, C Konradi, J Douglass, SE Hyman - Neuron, 1995 - Elsevier
Induction of prodynorphin gene expression by psychostimulant drugs may represent a
compensatory adaptation to excessive dopamine stimulation and may contribute to the aversive …

Amphetamine regulates gene expression in rat striatum via transcription factor CREB

C Konradi, RL Cole, S Heckers… - Journal of …, 1994 - Soc Neuroscience
Amphetamine is a psychostimulant drug of abuse that can produce long- lived changes in
behavior including sensitization and dependence. The neural substrates of these drug effects …

Neurotransmitter regulation of cellular activation and neuropeptide gene expression in the paraventricular nucleus of the hypothalamus

RL Cole, PE Sawchenko - Journal of Neuroscience, 2002 - Soc Neuroscience
Norepinephrine (NE), glutamate (Glu), and GABA have been identified as important
neurotransmitters governing neuroendocrine mechanisms represented in the paraventricular …

Differential distribution of voltage‐gated calcium channel alpha‐2 delta (α2δ) subunit mRNA‐containing cells in the rat central nervous system and the dorsal root …

RL Cole, SM Lechner, ME Williams… - Journal of …, 2005 - Wiley Online Library
Voltage‐gated calcium channels (VGCCs) play an essential role in controlling neurotransmitter
release, neuronal excitability, and gene expression in the nervous system. The …

Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition

G Gu, DS Lorrain, H Wei, RL Cole, X Zhang… - Brain research, 2008 - Elsevier
The receptor localization of metabotropic glutamate receptors (mGlu) 2 and 3 was examined
by using in situ hybridization and a well-characterized mGlu2-selective antibody in the rat …

Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons

MA Schwarzschild, RL Cole… - Journal of Neuroscience, 1997 - Soc Neuroscience
Drugs that stimulate dopamine and glutamate receptors have been shown to induce the
expression of AP-1 proteins (such as c-Fos and c-Jun) in the striatum and to induce binding of …

Noradrenergic neurons of the area postrema mediate amylin's hypophagic action

CS Potes, VF Turek, RL Cole, C Vu… - American Journal …, 2010 - journals.physiology.org
Circulating amylin inhibits food intake via activation of the area postrema (AP). The aim of
this study was to identify the neurochemical phenotype of the neurons mediating amylin's …

Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons

MA Schwarzschild, RL Cole, MA Meyers… - Journal of …, 1999 - Wiley Online Library
Stress‐activated protein kinase (SAPK) and extracellular signal‐regulated kinase (ERK),
both members of the mitogen‐activated protein kinase (MAPK) family, may in some …

Dopamine regulation of transcription factor-target interactions in rat striatum

SE Hyman, RL Cole, C Konradi… - Chemical senses, 1995 - academic.oup.com
Transcriptional regulation is an important mechanism by which neurons adapt to environmental
stimuli. The indirect dopamine agonists, amphetamine and cocaine have been shown to …