Antigen-specific T cell activation requires the engagement of the T cell receptor (TCR) with
antigen as well as the engagement of appropriate costimulatory molecules. The most …

A standard visual preference task was used to examine 3-month-olds' looking times at own-race
versus other-race faces as a function of environmental exposure to faces from the two …

Stimulation of T cell proliferation generally requires two signals: The first signal is provided by
the T cell receptor binding to antigen, and the second signal or costimulus is provided by a …

Costimulatory interactions between T and B lymphocytes are crucial for T cell activation and
B cell proliferation and differentiation. We have compared the roles of CD40L and B7-2 in …

The present study has assessed the replicative history and the residual replicative potential
of human naive and memory T cells. Telomeres are unique terminal chromosomal structures …

Telomerase, a ribonucleoprotein that is capable of synthesizing telomeric repeats, is expressed
in germline and malignant cells, and is absent in most normal human somatic cells. The …

Recent studies have indicated that adoptive immunotherapy with autologous antitumor
tumor-infiltrating lymphocytes (TILs) following nonmyeloablative chemotherapy mediates tumor …

B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T
cell proliferation. Blockade of this pathway results in T cell anergy. The in vivo role of B7 was …

Telomeres are the structures at the ends of linear chromosomes. In mammalian cells, they
consist of hexanucleotide (TTAGGG) repeats, together with many associated proteins. In the …

The function of the immune system is highly dependent on cellular differentiation and clonal
expansion of antigen-specific lymphocytes. However, little is known about mechanisms that …