Pericytes are essential for normal brain function, but many aspects of their physiology
remain enigmatic due to a lack of tools to genetically target this cell population. Here, we …

Smooth muscle cells and pericytes, together called mural cells, coordinate many distinct
vascular functions. Canonically, smooth muscle cells are ring-shaped and cover arterioles with …

Direct contact and communication between pericytes and endothelial cells is critical for
maintenance of cerebrovascular stability and blood-brain barrier function. Capillary pericytes …

Blood–brain barrier disruption (BBB) and release of toxic blood molecules into the brain
contributes to neuronal injury during stroke and other cerebrovascular diseases. While pericytes …

The neurovascular unit (NVU) coordinates many essential functions in the brain including
blood flow control, nutrient delivery, and maintenance of BBB integrity. These functions are the …

Pericytes and endothelial cells share membranous interdigitations called “peg-and-socket”
interactions that facilitate their adhesion and biochemical crosstalk during vascular …

Purpose: Anxiety-like (ANX) and depression-like (DEP) symptoms are common consequences
of traumatic brain injury (TBI). Environmental enrichment (EE) attenuates many deficits, …

Photothrombosis of blood vessels refers to the activation of a circulating photosensitive dye
with a green light to induce clotting in vivo (Watson et al., 1985). Previous studies have …

Nitric oxide serves essential roles in normal vascular physiology, but paradoxically contributes
to vascular pathology in disease. During brain ischemia, aberrant nitric oxide levels can …

… intense and multidisciplinary research to fully understand the biochemical and biological
steps of aging and move forward to develop plausible strategies that prevent the underlying …