Parkinson's disease (PD), a common neurodegenerative disease, is caused by loss of
dopaminergic neurons in the substantia nigra. Although the underlying cause of the neuronal loss …

Organism aging is characterized by increased inflammation and decreased stem cell function,
yet the relationship between these factors remains incompletely understood. This study …

Replication-based telomere shortening during lifetime is species-and tissue-specific, however,
its impact on healthy aging is unclear. In particular, the contribution of telomere truncation …

Objectives Infections, cancer, and systemic inflammation elicit anorexia. Despite the medical
significance of this phenomenon, the question of how peripheral inflammatory mediators …

Object To investigate the potential of a clinical 3 T scanner to perform MRI of small rodents.
Materials and methods Different dedicated small animal coils and several imaging …

Activation of nuclear factor kappa B (NF-κB) transcription factors is required for the induction
of synaptic plasticity and memory formation. All components of this signaling pathway are …

NF-κB is dually involved in neurogenesis and brain pathology. Here, we addressed its role
in adult axoneogenesis by generating mutations of RelA (p65) and p50 (also known as …

Activation of nuclear factor kappa B (NF-κB) is a hallmark of various central nervous system (CNS)
pathologies. Neuron-specific inhibition of its transcriptional activator subunit RelA, …

Traditionally, depiction of isolated CNS fiber tracts is achieved by histological post mortem
studies. As a tracer-dependent strategy, the calcium analog manganese has proved valuable …

TRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component.
Trip6 deletion in the mouse, reported here, reveals a function in the brain: ependymal and …