Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every
cell type. EVs have diverse biological activities, ranging from roles in development and …

While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear,
other brain-resident myeloid cells remain less well understood. By dissecting border regions …

Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases, …

Nonviral gene complexes can enter mammalian cells through different endocytic pathways.
For efficient optimization of the gene carrier it is important to profile its cellular uptake, …

… Author links open overlay panel Sophie Steeland 1 2 , Roosmarijn E. Vandenbroucke 1 2 3
… Clostridium botulinum In vivo Mice 10 x LD 50 BoNT/A1 or BoNT/E challenge Also effective …

‘Hollow’polyelectrolyte capsules,[1, 2] fabricated by coating colloidal templates by using a
layer-by-layer (LbL) technique [3–6] followed by dissolution of the core material, have recently …

According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–related
protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to …

Alzheimer’s disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of which …

Here, we identified release of extracellular vesicles (EVs) by the choroid plexus epithelium (
CPE ) as a new mechanism of blood–brain communication. Systemic inflammation induced …