Whole organism–based small-molecule screens have proven powerful in identifying novel
therapeutic chemicals, yet this approach has not been exploited to identify new cognitive …

Autism spectrum disorders (ASDs) are a group of devastating neurodevelopmental syndromes
that affect up to 1 in 68 children. Despite advances in the identification of ASD risk genes, …

Habituation represents a fundamental form of learning, yet the underlying molecular genetic
mechanisms are not well defined. Here we report on a genome-wide genetic screen, …

Translational control of gene expression plays a fundamental role in the early development
of many organisms. In Drosophila, selective translation of nanos mRNA localized to the germ …

Sensory experiences dynamically modify whether animals respond to a given stimulus, but
it is unclear how innate behavioral thresholds are established. Here, we identify molecular …

Asymmetric mRNA localization is an effective mechanism for establishing cellular and
developmental polarity. Posterior localization of oskar in the Drosophila oocyte targets the …

Animals continuously integrate sensory information and select contextually appropriate
responses. Here, we show that zebrafish larvae select a behavioral response to acoustic stimuli …

Olfactory sensory neurons expressing particular olfactory receptors project to specific
reproducible locations within the bulb. The axonal guidance cues that organize this precise …

Decision making is a fundamental nervous system function that ranges widely in complexity
and speed of execution. We previously established larval zebrafish as a model for …

Anterior-posterior axis patterning of the Drosophila embryo requires Nanos activity selectively
in the posterior. This spatial asymmetry of Nanos is generated by the localization of nanos …