The Morris water maze (MWM) was described 20 years ago as a device to investigate spatial
learning and memory in laboratory rats. In the meanwhile, it has become one of the most …

Rhomboids, evolutionarily conserved integral membrane proteases, participate in crucial
signaling pathways. Presenilin-associated rhomboid-like (PARL) is an inner mitochondrial …

Male patients with fragile X syndrome lack FMR1 protein due to silencing of the FMR1 gene
by amplification of a CGG repeat and subsequent methylation of the promoter region. The …

The amyloid peptides Aβ 40 and Aβ 42 of Alzheimer's disease are thought to contribute
differentially to the disease process. Although Aβ 42 seems more pathogenic than Aβ 40 , the …

β-Secretase (BACE1) is the rate-limiting protease for the generation of the amyloid β-peptide
(Aβ) in Alzheimer disease. Mice in which the bace1 gene is inactivated are reported to be …

Although soluble oligomeric and protofibrillar assemblies of Aβ‐amyloid peptide cause
synaptotoxicity and potentially contribute to Alzheimer's disease (AD), the role of mature Aβ‐…

Heterozygous APP23 mice, expressing human amyloid‐precursor protein with the Swedish
double mutation and control littermates, were subjected to behavioral and neuromotor tasks …

This report describes the behavioral and electrophysiological analysis of regulatable transgenic
mice expressing mutant repeat domains of human Tau (Tau RD ). Mice were generated …

The γ-secretase complex plays a role in Alzheimer’s disease and cancer progression. The
development of clinically useful inhibitors, however, is complicated by the role of the γ-…

Action myoclonus-renal failure syndrome (AMRF) is an autosomal-recessive disorder with
the remarkable combination of focal glomerulosclerosis, frequently with glomerular collapse, …