Although the neurogenesis-enhancing effects of exercise have been extensively studied,
the molecular mechanisms underlying this response remain unclear. Here, we propose that …

Stroke is a major cause of serious disability due to the brain’s limited capacity to regenerate
damaged tissue and neuronal circuits. After ischemic injury, a multiphasic degenerative and …

The apolipoprotein E4 (APOE4) variant is the strongest genetic risk factor for Alzheimer
disease (AD), while the APOE2 allele is protective. A major question is how different APOE …

Injuries to the CNS lead to severe and often irreversible deficits in sensorimotor and
autonomous function. In spinal cord injury (SCI), mechanical damage results in the death of local …

Background Stroke research heavily relies on rodent behavior when assessing underlying
disease mechanisms and treatment efficacy. Although functional motor recovery is …

Blood vessels nurture every part of the human body. Consequently, abnormalities in the
vasculature are closely associated with a variety of diseases, including cerebral stroke, heart …

As disease-specific interventions for dementia are being developed, the ability to identify the
underlying pathology and dementia subtypes is increasingly important. Vascular cognitive …

Stem cell therapy has been shown to improve stroke outcomes in animal models and is
currently advancing towards clinical practice. However, uncertainty remains regarding the …

Nogo-A is a transmembrane protein with multiple functions in the central nervous system (CNS),
including restriction of neurite growth and synaptic plasticity. Thus far, Nogo-A has been …

Stroke patients are often left with permanent disabilities with no regenerative treatment
options. Unbiased RNA sequencing studies decoding the transcriptional signature of stroked …