Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in
numerous biological processes, largely through their repressive influence on transcription. …

Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression
through the removal of acetyl groups from histone tails. The class I HDACs, HDAC1 and HDAC2…

Background— Diastolic dysfunction in response to hypertrophy is a major clinical syndrome
with few therapeutic options. MicroRNAs act as negative regulators of gene expression by …

Oligodendrocyte development is regulated by the interaction of repressors and activators in
a complex transcriptional network. We found that two histone-modifying enzymes, HDAC1 …

Rationale: Myocardial infarction (MI) is a leading cause of death worldwide. Because
endogenous cardiac repair mechanisms are not sufficient for meaningful tissue regeneration, MI …

MicroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary
sequences in 3′ untranslated regions of target mRNAs. MicroRNA-21 (miR-21) is …

Histone deacetylase (HDAC) inhibitors show remarkable therapeutic potential for a variety
of disorders, including cancer, neurological disease, and cardiac hypertrophy. However, the …

The molecular mechanism by which neural progenitor cells commit to a specified lineage of
the central nervous system remains unknown. We show that HDAC1 and HDAC2 …

Histone deacetylases (Hdacs) are transcriptional repressors with crucial roles in mammalian
development. Here we provide evidence that Hdac8 specifically controls patterning of the …

The molecular mechanisms underlying the transition from recreational drug use to chronic
addiction remain poorly understood. One molecule implicated in this process is ΔFosB, a …