Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy

FH Yu, M Mantegazza, RE Westenbroek… - Nature …, 2006 - nature.com
Voltage-gated sodium channels (Na V ) are critical for initiation of action potentials. Heterozygous
loss-of-function mutations in Na V 1.1 channels cause severe myoclonic epilepsy in …

Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits.

JW Hell, RE Westenbroek, C Warner… - The Journal of cell …, 1993 - rupress.org
To identify and localize the protein products of genes encoding distinct L-type calcium channels
in central neurons, anti-peptide antibodies specific for the class C and class D alpha 1 …

Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels

RE Westenbroek, T Sakurai, EM Elliott… - Journal of …, 1995 - Soc Neuroscience
A site-directed anti-peptide antibody (anti-CNA1) directed against the alpha 1 subunit of
class A calcium channels (alpha 1A) recognized a protein of approximately 190-200 kDa in …

Biochemical properties and subcellular distribution of an N-type calcium hannel α1 subunit

RE Westenbroek, JW Hell, C Warner, SJ Dubel… - Neuron, 1992 - cell.com
A site-directed anti-peptide antibody, CNB-1, that recognizes the α1 subunit of rat brain class
B calcium channels (rbB) immunoprecipitated 43% of the N-type calcium channels labeled …

Autistic-like behaviour in Scn1a+/− mice and rescue by enhanced GABA-mediated neurotransmission

S Han, C Tai, RE Westenbroek, FH Yu, CS Cheah… - Nature, 2012 - nature.com
Haploinsufficiency of the SCN1A gene encoding voltage-gated sodium channel Na V 1.1
causes Dravet’s syndrome, a childhood neuropsychiatric disorder including recurrent …

CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm

AE Carlson, RE Westenbroek, T Quill… - Proceedings of the …, 2003 - National Acad Sciences
CatSper family proteins are putative ion channels expressed exclusively in membranes of
the sperm flagellum and required for male fertility. Here, we show that mouse CatSper1 is …

Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons

RE Westenbroek, DK Merrick, WA Catterall - Neuron, 1989 - cell.com
tmmunocytochemical localization of Na+ channel subtypes RI and RI1 showed that RI
immunoreactivity is relatively low and homogeneous along the rostral-caudal extent of sagittal …

Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.

FH Yu, RE Westenbroek, I Silos-Santiago… - The Journal of …, 2003 - europepmc.org
The principal α subunit of voltage-gated sodium channels is associated with auxiliary β
subunits that modify channel function and mediate protein-protein interactions. We have …

Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses

LG Wu, RE Westenbroek, JGG Borst… - Journal of …, 1999 - Soc Neuroscience
We studied how Ca 2+ influx through different subtypes of Ca 2+ channels couples to release
at a calyx-type terminal in the rat medial nucleus of the trapezoid body by simultaneously …

Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons

RE Westenbroek, MK Ahlijanian, WA Catterall - Nature, 1990 - nature.com
INTEGRATION and processing of electrical signals in individual neurons depend critically
on the spatial distribution of ion channels on the cell surface. In hippocampal pyramidal …