[HTML][HTML] Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
In contrast to the well-established roles of PPARγ and PPARα in lipid metabolism, little is
known for PPARδ in this process. We show here that targeted activation of PPARδ in adipose …
known for PPARδ in this process. We show here that targeted activation of PPARδ in adipose …
[HTML][HTML] AMPK and PPARδ agonists are exercise mimetics
The benefits of endurance exercise on general health make it desirable to identify orally
active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. …
active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. …
[HTML][HTML] Regulation of muscle fiber type and running endurance by PPARδ
Endurance exercise training can promote an adaptive muscle fiber transformation and an
increase of mitochondrial biogenesis by triggering scripted changes in gene expression. …
increase of mitochondrial biogenesis by triggering scripted changes in gene expression. …
[HTML][HTML] Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
In multicellular organisms, the ability to regulate reproduction, development, and nutrient
utilization coincided with the evolution of nuclear receptors (NRs), transcription factors that …
utilization coincided with the evolution of nuclear receptors (NRs), transcription factors that …
[HTML][HTML] Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to
intrinsic chemoresistance and a growth-permissive tumor microenvironment. Conversion of …
intrinsic chemoresistance and a growth-permissive tumor microenvironment. Conversion of …
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
…, L Peng, G Zhao, M Downes, RT Yu… - Proceedings of the …, 2006 - National Acad Sciences
Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small
intestine that can lead to the translocation of bacteria across the epithelial barrier and systemic …
intestine that can lead to the translocation of bacteria across the epithelial barrier and systemic …
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
The circadian clock acts at the genomic level to coordinate internal behavioural and
physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the nuclear …
physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the nuclear …
[HTML][HTML] Nuclear receptor expression links the circadian clock to metabolism
As sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR)
expression in key metabolic tissues may contribute to circadian entrainment of nutrient and …
expression in key metabolic tissues may contribute to circadian entrainment of nutrient and …
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to
promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic …
promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic …
[HTML][HTML] A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response
N Ding, TY Ruth, N Subramaniam, MH Sherman… - Cell, 2013 - cell.com
Liver fibrosis is a reversible wound-healing response involving TGFβ1/SMAD activation of
hepatic stellate cells (HSCs). It results from excessive deposition of extracellular matrix …
hepatic stellate cells (HSCs). It results from excessive deposition of extracellular matrix …