User profiles for Ryoichiro Kageyama
Ryoichiro KageyamaRIKEN Center for Brain Science / Kyoto University Verified email at riken.jp Cited by 44244 |
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
…, K Mori, T Ikeda, S Itohara, R Kageyama - Nature …, 2008 - nature.com
Neurogenesis occurs continuously in the forebrain of adult mammals, but the functional
importance of adult neurogenesis is still unclear. Here, using a genetic labeling method in adult …
importance of adult neurogenesis is still unclear. Here, using a genetic labeling method in adult …
Control of endodermal endocrine development by Hes-1
…, J Hald, RS Heller, M Ishibashi, R Kageyama… - Nature …, 2000 - nature.com
Abstract Development of endocrine cells in the endoderm involves Atonal and Achaete/Scute-related
basic helix-loop-helix (bHLH) proteins. These proteins also serve as neuronal …
basic helix-loop-helix (bHLH) proteins. These proteins also serve as neuronal …
Roles of bHLH genes in neural stem cell differentiation
R Kageyama, T Ohtsuka, J Hatakeyama… - Experimental cell …, 2005 - Elsevier
Neural stem cells change their characteristics over time during development: they initially
proliferate only and then give rise to neurons first and glial cells later. In the absence of the …
proliferate only and then give rise to neurons first and glial cells later. In the absence of the …
[HTML][HTML] The Notch-Hes pathway in mammalian neural development
R Kageyama, T Ohtsuka - Cell research, 1999 - nature.com
A wide variety of neurons and glial cells differentiate from common precursor cells in the
developing nervous system. During this process, Notch-mediated cell-cell interaction is …
developing nervous system. During this process, Notch-mediated cell-cell interaction is …
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop
…, Y Bessho, T Harada, K Yoshikawa, R Kageyama - Science, 2002 - science.org
Transcription of messenger RNAs (mRNAs) for Notch signaling molecules oscillates with 2-hour
cycles, and this oscillation is important for coordinated somite segmentation. However, …
cycles, and this oscillation is important for coordinated somite segmentation. However, …
Dynamic expression and essential functions of Hes7 in somite segmentation
…, K Shiota, S Yamada, R Kageyama - Genes & …, 2001 - genesdev.cshlp.org
The basic helix–loop–helix (bHLH) gene Hes7, a putative Notch effector, encodes a
transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the …
transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the …
The Hes gene family: repressors and oscillators that orchestrate embryogenesis
R Kageyama, T Ohtsuka, T Kobayashi - 2007 - journals.biologists.com
Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The
mammalian Hes basic helix-loop-helix repressor genes play central roles in these …
mammalian Hes basic helix-loop-helix repressor genes play central roles in these …
[HTML][HTML] Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation
…, S Nakanishi, F Guillemot, R Kageyama - The EMBO …, 1999 - embopress.org
While the transmembrane protein Notch plays an important role in various aspects of
development, and diseases including tumors and neurological disorders, the intracellular pathway …
development, and diseases including tumors and neurological disorders, the intracellular pathway …
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis …
…, K Shiota, S Nakanishi, R Kageyama… - Genes & …, 1995 - genesdev.cshlp.org
Mammalian hairy and Enhancer of split homolog-1 (HES-1) encodes a helix-loop-helix (HLH)
factor that is thought to act as a negative regulator of neurogenesis. To directly investigate …
factor that is thought to act as a negative regulator of neurogenesis. To directly investigate …
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.
Y Sasai, R Kageyama, Y Tagawa… - Genes & …, 1992 - genesdev.cshlp.org
We report the molecular characterization of two novel rat helix-loop-helix (HLH) proteins,
designated HES-1 and HES-3, that show structural homology to the Drosophila hairy and …
designated HES-1 and HES-3, that show structural homology to the Drosophila hairy and …