Neurogenesis occurs continuously in the forebrain of adult mammals, but the functional
importance of adult neurogenesis is still unclear. Here, using a genetic labeling method in adult …

Abstract Development of endocrine cells in the endoderm involves Atonal and Achaete/Scute-related
basic helix-loop-helix (bHLH) proteins. These proteins also serve as neuronal …

Neural stem cells change their characteristics over time during development: they initially
proliferate only and then give rise to neurons first and glial cells later. In the absence of the …

A wide variety of neurons and glial cells differentiate from common precursor cells in the
developing nervous system. During this process, Notch-mediated cell-cell interaction is …

Transcription of messenger RNAs (mRNAs) for Notch signaling molecules oscillates with 2-hour
cycles, and this oscillation is important for coordinated somite segmentation. However, …

The basic helix–loop–helix (bHLH) gene Hes7, a putative Notch effector, encodes a
transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the …

Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The
mammalian Hes basic helix-loop-helix repressor genes play central roles in these …

While the transmembrane protein Notch plays an important role in various aspects of
development, and diseases including tumors and neurological disorders, the intracellular pathway …

Mammalian hairy and Enhancer of split homolog-1 (HES-1) encodes a helix-loop-helix (HLH)
factor that is thought to act as a negative regulator of neurogenesis. To directly investigate …

We report the molecular characterization of two novel rat helix-loop-helix (HLH) proteins,
designated HES-1 and HES-3, that show structural homology to the Drosophila hairy and …