Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment
…, ML Cohen, X Wang, SL Siedlak… - Journal of …, 2010 - content.iospress.com
… , change that occurs in the pathogenesis of Alzheimer’s disease (AD). Consistent with this,
mild … and statistical differences between groups were determined using the Student’s t-test. …
mild … and statistical differences between groups were determined using the Student’s t-test. …
Vascular oxidative stress in Alzheimer disease
…, G Casadesus, PLR Harris, SL Siedlak… - Journal of the …, 2007 - Elsevier
Alzheimer disease and cerebrovascular dementia are two common causes of dementia and,
by present diagnostic criteria, are mutually exclusive using vascular pathology as an …
by present diagnostic criteria, are mutually exclusive using vascular pathology as an …
Neurofilament proteins in neurodegenerative diseases
Q Liu, F Xie, SL Siedlak, A Nunomura, K Honda… - Cellular and Molecular …, 2004 - Springer
… , using green fluorescent protein (GFP)tagged NF subunits and live cell imaging, two research
groups found a fast transport of NF polymers down the axon at a rate up to 2 mm/s [54, 55] …
groups found a fast transport of NF polymers down the axon at a rate up to 2 mm/s [54, 55] …
Mitochondrial abnormalities in Alzheimer's disease
…, S Shimohama, AD Cash, SL Siedlak… - Journal of …, 2001 - Soc Neuroscience
The finding that oxidative damage, including that to nucleic acids, in Alzheimer's disease is
primarily limited to the cytoplasm of susceptible neuronal populations suggests that …
primarily limited to the cytoplasm of susceptible neuronal populations suggests that …
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Mitochondrial dysfunction is a prominent feature of Alzheimer disease but the underlying
mechanism is unclear. In this study, we investigated the effect of amyloid precursor protein (APP…
mechanism is unclear. In this study, we investigated the effect of amyloid precursor protein (APP…
Metal binding and oxidation of amyloid-β within isolated senile plaque cores: Raman microscopic evidence
J Dong, CS Atwood, VE Anderson, SL Siedlak… - Biochemistry, 2003 - ACS Publications
Alzheimer's disease (AD) is characterized by the deposition of amyloid plaques in the
parenchyma and vasculature of the brain. Although previous analytical studies have provided …
parenchyma and vasculature of the brain. Although previous analytical studies have provided …
Amyloid‐β deposition in Alzheimer transgenic mice is associated with oxidative stress
…, MA Pappolla, PLR Harris, SL Siedlak… - Journal of …, 1998 - Wiley Online Library
… In transgenic animals with amyloid-/3 deposits, we noted all the features ofoxidative stress
foundin Alzheimer’s disease (Figs. 1 and 2 and Table 1). It is interesting that parameters of …
foundin Alzheimer’s disease (Figs. 1 and 2 and Table 1). It is interesting that parameters of …
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity
… The sections were then subject to antigen retrieval under pressure using Biocare's Decloaking
Chamber by heating to 125 C for 10 s and cooling to 90 C for 30 s, followed by heating to …
Chamber by heating to 125 C for 10 s and cooling to 90 C for 30 s, followed by heating to …
Skin α-synuclein aggregation seeding activity as a novel biomarker for Parkinson disease
Z Wang, K Becker, V Donadio, S Siedlak, J Yuan… - JAMA …, 2021 - jamanetwork.com
Importance Deposition of the pathological α-synuclein (αSyn P ) in the brain is the hallmark
of synucleinopathies, including Parkinson disease (PD), Lewy body dementia (LBD), and …
of synucleinopathies, including Parkinson disease (PD), Lewy body dementia (LBD), and …
[HTML][HTML] Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron
…, AM Tartakoff, T Hattier, PL Harris, SL Siedlak… - Journal of Biological …, 2005 - ASBMB
Oxidative modification of cytoplasmic RNA in vulnerable neurons is an important, well
documented feature of the pathophysiology of Alzheimer disease. Here we report that RNA-bound …
documented feature of the pathophysiology of Alzheimer disease. Here we report that RNA-bound …