Loss of FBXO 7 (PARK 15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in mice

…, N Schwedhelm‐Domeyer, S Joseph… - The EMBO …, 2016 - embopress.org
Mutations in the FBXO 7 ( PARK 15) gene have been implicated in a juvenile form of
parkinsonism termed parkinsonian pyramidal syndrome ( PPS ), characterized by Parkinsonian …

Mechanistic contributions of FBXO7 to Parkinson disease

S Joseph, JB Schulz, J Stegmüller - Journal of neurochemistry, 2018 - Wiley Online Library
Parkinson disease (PD) is, without doubt, a burden on modern society as the prevalence
increases significantly with age. Owing to this growing number of PD cases, it is more critical …

Loss of the parkinsonism‐associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects

J Wang, S Joseph, S Vingill, E Dere… - Journal of …, 2023 - Wiley Online Library
Mutations in PARK15, which encodes for the F‐box protein FBXO7 have been associated
with Parkinsonian Pyramidal syndrome, a rare and complex movement disorder with …

Myelinating glia-specific deletion of Fbxo7 in mice triggers axonal degeneration in the central nervous system together with peripheral neuropathy

S Joseph, S Vingill, O Jahn, R Fledrich… - Journal of …, 2019 - Soc Neuroscience
Myelination of axons facilitates the rapid propagation of electrical signals and the long-term
integrity of axons. The ubiquitin-proteasome system is essential for proper protein …

Gallyas silver impregnation of myelinated nerve fibers

S Joseph, HB Werner, J Stegmüller - Bio-protocol, 2019 - bio-protocol.org
In the nervous system of vertebrates, nerve impulse propagation is accelerated by the
ensheathment of neuronal axons with myelin. Myelin sheaths are molecularly specialized, lipid-…

[PDF][PDF] A novel role for the E3 ubiquitin ligase FBXO7 in axon-myelin interaction

SL Joseph - 2018 - pure.mpg.de
I further would like to highlight, how much I appreciate the incredible effort and immense
support that the coordinators (Prof. Dr. Michael Hörner and Sandra Drube) of the IMPRS …

In-vitro and in-silico strategies to assess the unexplored pharmacological lineages of Solanum elaeagnifolium Cav. Leaves

TF Xavier, R Sabitha, R Kariyat, AKF Rose, M Ayyanar… - 2022 - researchsquare.com
The current work aims to investigate the chemical components in Solanum elaeagnifolium
leaf extracts and their pharmacological potential in antioxidant, antibacterial and anti-diabetic …

Effectiveness of antenatal care package on knowledge of pregnancy induced hypertension for antenatal mothers in selected hospitals of mangalore

SJ Joseph, S Nayak, P Fernandes… - Journal of Health and …, 2013 - thieme-connect.com
The study was conducted on effectiveness of antenatal care package on knowledge of
pregnancy induced hypertension for antenatal mothers from 7/09/2009 to 10/10/2009. The …

[PDF][PDF] Evaluation of egg quality traits and cholesterol content of eggs of Aseel crossbreds

S Antony, L Joseph, PA Peethambaran, P Anitha - 2023 - thepharmajournal.com
An experiment was conducted to evaluate and compare the egg quality traits of eggs
obtained from hens of Aseel× Naked Neck (ANN), Aseel× New Hampshire (ANH) and Aseel× …

[HTML][HTML] Stimuli-responsive polymeric nanosystem for colon specific drug delivery

SK Joseph, M Sabitha, SC Nair - Advanced pharmaceutical bulletin, 2020 - ncbi.nlm.nih.gov
An ideal colon specific drug delivery system needs to perform multiple functions like greater
bio availability, less toxicity and higher therapeutic efficacy, all of which require high degree …