[HTML][HTML] Mutagenesis identifies new signals for β-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Aβ42
RG Perez, S Soriano, JD Hayes, B Ostaszewski… - Journal of Biological …, 1999 - ASBMB
It has long been assumed that the C-terminal motif, NPXY, is the internalization signal for β-amyloid
precursor protein (APP) and that the NPXY tyrosine (Tyr 743 by APP751 numbering, …
precursor protein (APP) and that the NPXY tyrosine (Tyr 743 by APP751 numbering, …
Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis
X Xia, S Qian, S Soriano, Y Wu… - Proceedings of the …, 2001 - National Acad Sciences
Presenilin 1 (PS1) is required for the proteolytic processing of Notch and the β-amyloid
precursor protein (APP), molecules that play pivotal roles in cell-fate determination during …
precursor protein (APP), molecules that play pivotal roles in cell-fate determination during …
[HTML][HTML] Presenilin couples the paired phosphorylation of β-catenin independent of axin: implications for β-catenin activation in tumorigenesis
DE Kang, S Soriano, X Xia, CG Eberhart… - Cell, 2002 - cell.com
The Alzheimer's disease-linked gene presenilin 1 (PS1) is required for intramembrane
proteolysis of APP and Notch. In addition, recent observations strongly implicate PS1 as a …
proteolysis of APP and Notch. In addition, recent observations strongly implicate PS1 as a …
Presenilin 1 negatively regulates β-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of β-amyloid precursor protein and notch processing
S Soriano, DE Kang, M Fu, R Pestell… - The Journal of cell …, 2001 - rupress.org
In addition to its documented role in the proteolytic processing of Notch-1 and the β-amyloid
precursor protein, presenilin 1 (PS1) associates with β-catenin. In this study, we show that …
precursor protein, presenilin 1 (PS1) associates with β-catenin. In this study, we show that …
On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis
MA Castello, S Soriano - Ageing research reviews, 2014 - Elsevier
The amyloid cascade hypothesis, which implicates the amyloid Aβ peptide as the pathological
initiator of both familial and sporadic, late onset Alzheimer's disease (AD), continues to …
initiator of both familial and sporadic, late onset Alzheimer's disease (AD), continues to …
Presenilin 1 facilitates the constitutive turnover of β-catenin: differential activity of Alzheimer's disease–linked PS1 mutants in the β-catenin–signaling pathway
DE Kang, S Soriano, MP Frosch, T Collins… - Journal of …, 1999 - Soc Neuroscience
Although an association between the product of the familial Alzheimer’s disease (FAD) gene,
presenilin 1 (PS1), and β-catenin has been reported recently, the cellular consequences of …
presenilin 1 (PS1), and β-catenin has been reported recently, the cellular consequences of …
Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation
NL Chevallier, S Soriano, DE Kang, E Masliah… - The American journal of …, 2005 - Elsevier
In addition to its well-established role in γ-secretase cleavage, presenilin (PS) also plays a
role in regulating the stability of cytosolic β-catenin, a protein involved in Wnt signaling. …
role in regulating the stability of cytosolic β-catenin, a protein involved in Wnt signaling. …
[HTML][HTML] The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease
A Currais, T Hortobágyi, S Soriano - Aging, 2009 - ncbi.nlm.nih.gov
Differentiated neurons display specific biochemical, physiological and morphological properties
that apparently prevent them from further cell division. Nevertheless, expression of cell …
that apparently prevent them from further cell division. Nevertheless, expression of cell …
Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity
DC Lu, S Soriano, DE Bredesen… - Journal of …, 2003 - Wiley Online Library
The amyloid β‐protein precursor (APP) is proteolytically cleaved to generate the amyloid β‐protein
(Aβ), the principal constituent of senile plaques found in Alzheimer's disease (AD). In …
(Aβ), the principal constituent of senile plaques found in Alzheimer's disease (AD). In …
[HTML][HTML] Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer's disease
MA Castello, JD Jeppson, S Soriano - BMC neurology, 2014 - Springer
Background High-profile Phase 3 clinical trials of bapineuzumab and solanezumab,
antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. …
antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. …