Mutations in leucine-rich glioma inactivated (LGI1) are a genetic cause of autosomal
dominant temporal lobe epilepsy with auditory features. LGI1 is a secreted protein that shares …

The sulfamide moiety has been utilized to design novel HDAC inhibitors. The potency and
selectivity of these inhibitors were influenced both by the nature of the scaffold, and the …

Neurons fail to re-extend their processes within the central nervous system environment in
vivo, and this is partly because of inhibitory proteins expressed within myelin debris and …

Cells respond to extracellular stimuli by initiating specific intracellular events, such as the
signaling cascade that leads to activation of the mitogen-activated protein kinases (MAPKs), a …

… , as well as to Christine Paul and Samuel Montcalm who aided me in the numerous and …
On a personal note, 1 would like to thank Sam for his friendship and support; you have truly …

The p75 neurotrophin receptor (p75NTR) is a type 1 transmembrane protein which, under
certain circumstances, can activate the JNK mediated apoptotic pathway. p75NTR was …

The development of the nervous system requires the spatial and temporally controlled
elimination of supernumerary neurons and their precursors. A balance between pro-survival and …

In 2001, about 15 years after the identification of p75NTR as a neurotrophin receptor, this
receptor was found to bind to the pro-, unproteolytically processed, forms of the neurotrophins …

The neurotrophins are a well conserved family of proteins which play critical roles in the
maintenance and development of the nervous system (Cowley et al., 1994; Emfors et al., 1994a, …

We have performed an experimental investigation of Ti-, B_4C-, B-, and Y-based multilayer
mirrors for the soft x-ray–extreme ultraviolet (XUV) wavelength region between 2.0 and 12.0 …