User profiles for Samuel R. W. Legg
Samuel RW LeggFred Hutch Cancer Center Verified email at fredhutch.org Cited by 58 |
Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity
…, CR Schmidt, SS Bhise, SRW Legg… - Science …, 2022 - science.org
Some hematological malignancies such as multiple myeloma are inherently resistant to
immune-mediated antitumor responses, the cause of which remains unknown. Allogeneic bone …
immune-mediated antitumor responses, the cause of which remains unknown. Allogeneic bone …
Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to huntington's disease mutations
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …
Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation
Huntington’s disease arises from a toxic gain of function in the huntingtin (HTT) gene. As a
result, many HTT-lowering therapies are being pursued in clinical studies, including those …
result, many HTT-lowering therapies are being pursued in clinical studies, including those …
[HTML][HTML] TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice
Autologous stem cell transplantation (ASCT) with subsequent lenalidomide maintenance is
standard consolidation therapy for multiple myeloma, and a subset of patients achieve …
standard consolidation therapy for multiple myeloma, and a subset of patients achieve …
[HTML][HTML] Early detection of apathetic phenotypes in Huntington's disease knock-in mice using open source tools
…, WS Hovander, EMS Vik, M Hamilton, SRW Legg… - Scientific Reports, 2018 - nature.com
Apathy is one of the most prevalent and progressive psychiatric symptoms in Huntington’s
disease (HD) patients. However, preclinical work in HD mouse models tends to focus on …
disease (HD) patients. However, preclinical work in HD mouse models tends to focus on …
Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation
…, KS Ensbey, CR Schmidt, T Sekiguchi, SRW Legg… - Blood, 2024 - Elsevier
Autologous stem cell transplantation (ASCT) is the standard of care consolidation therapy for
eligible patients with myeloma but most patients eventually progress, an event associated …
eligible patients with myeloma but most patients eventually progress, an event associated …
Regulatory T Cell Depletion during Stem Cell Mobilization Enhances Anti-Myeloma Immunity after Experimental Autologous Stem Cell Transplantation
S Takahashi, SA Minnie, SRW Legg, CR Schmidt… - Blood, 2022 - ashpublications.org
Autologous stem cell transplantation (ASCT) with G-CSF/plerixafor mobilized peripheral
blood stem cells (PBSC) remains the standard of care for newly diagnosed eligible multiple …
blood stem cells (PBSC) remains the standard of care for newly diagnosed eligible multiple …
[HTML][HTML] The IL-2/IL-15 Mimetic NL-201 Prevents Myeloma Relapse after ASCT By Expanding Highly Cytolytic T Cells in the Bone Marrow That Are Resistant to …
…, S Takahashi, CR Schmidt, SRW Legg… - Blood, 2021 - Elsevier
Multiple myeloma (MM) is a bone marrow (BM) resident hematological malignancy that is
becoming increasingly recognized as one amenable to immunotherapy, although no therapies …
becoming increasingly recognized as one amenable to immunotherapy, although no therapies …
Type-1 regulatory T cells are critical for curative immunotherapy outcomes
IL-10 producing CD4+ type-1 regulatory T cells (Tr1) mediate immune tolerance during
chronic infection, autoimmunity, and transplantation. We previously demonstrated that …
chronic infection, autoimmunity, and transplantation. We previously demonstrated that …
[PDF][PDF] Problems and prospects in large-scale ocean circulation models
…, HL Simmons, J Schröter, BL Samuels… - Proceedings of …, 2009 - researchgate.net
Numerical ocean circulation models support oceanography and climate science by
providing tools to mechanistically interpret ocean observations, to experimentally investigate …
providing tools to mechanistically interpret ocean observations, to experimentally investigate …