The development of alcohol dependence is posited to involve numerous changes in brain
chemistry (ie, neurotransmission) that lead to physiological signs of withdrawal upon …

Cerebellar granule neurons cultured in medium containing a physiological concentration of
KCl (5 mm) undergo apoptosis. The cells can be rescued by the in vitroaddition of NMDA. …

When primary cultures of cerebellar granule neurons are grown in a physiological concentration
of KCl (5 mM) they undergo apoptosis, which can be prevented by growing the cells in …

Searches for the identity of genes that influence the levels of alcohol consumption by humans
and other animals have often been driven by presupposition of the importance of particular …

Acute functional tolerance to ethanol develops during a single exposure to ethanol; it has
been suggested to be a predisposing factor for the development of ethanol dependence. …

QTL analysis of behavioral traits and mouse brain gene expression studies were combined
to identify candidate genes involved in the traits of alcohol preference and acute functional …

Major depression represents a complex mental disorder. The identification of biological
markers that define subtypes of major depressive disorder would greatly facilitate appropriate …

Background With the advent of "omics" (eg genomics, transcriptomics, proteomics and
phenomics), studies can produce enormous amounts of data. Managing this diverse data and …

Cerebellar granule neurons cultured in the presence of 5 mm KCl undergo spontaneous
apoptosis, which is reduced by exposure to pituitary adenylyl cyclase‐activating polypeptide (…

Alcohol “sensitivity” has been proposed as a predictive factor for development of alcohol
dependence ( Schuckit et al., 2005 ). Most measures of alcohol sensitivity in humans and …