It is well established that the proteolytic processing of the β-amyloid precursor protein (APP)
generates β-amyloid (Aβ), which plays a central role in the pathogenesis of Alzheimer's …

Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid
precursor protein (APP) and its proteolytic fragments are still poorly understood. Previously, …

The key role of APP in the pathogenesis of Alzheimer disease is well established. However,
postnatal lethality of double knockout mice has so far precluded the analysis of the …

Alzheimer’s disease (AD) is characterized by synaptic failure, dendritic and axonal atrophy,
neuronal death and progressive loss of cognitive functions. It is commonly assumed that …

It is known that activity modulates neuronal differentiation in the adult brain but the signalling
mechanisms underlying this process remain to be identified. We show here that activity …

Amyloid precursor protein (APP) is critically involved in the pathophysiology of Alzheimer’s
disease, but its physiological functions remain elusive. Importantly, APP knockout (APP-KO) …

The amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer’s
disease (AD), as proteolytical cleavage of APP gives rise to the β-amyloid peptide which is …

Synaptic dysfunction and synapse loss are key features of Alzheimer’s pathogenesis.
Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning …

Increasing evidence suggests that synaptic functions of the amyloid precursor protein ( APP
), which is key to Alzheimer pathogenesis, may be carried out by its secreted ectodomain ( …

The amyloid precursor protein family (APP/APLPs) has essential roles for neuromuscular
synapse development and for the formation and plasticity of synapses within the CNS. Despite …