Compromised axon initial segment integrity in EAE is preceded by microglial reactivity and contact

KC Clark, A Josephson, SD Benusa, RK Hartley… - Glia, 2016 - Wiley Online Library
Axonal pathology is a key contributor to long‐term disability in multiple sclerosis (MS), an
inflammatory demyelinating disease of the central nervous system (CNS), but the mechanisms …

Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes

…, MG Dozmorov, JC Stansfield, SD Benusa… - …, 2021 - nature.com
Adolescent exposure to chronic stress, a risk factor for mood disorders in adulthood, sensitizes
the neuroinflammatory response to a subsequent immune challenge. We previously …

[HTML][HTML] Microglial process convergence on axonal segments in health and disease

SD Benusa, AD Lafrenaye - Neuroimmunology and …, 2020 - ncbi.nlm.nih.gov
Microglia dynamically interact with neurons influencing the development, structure, and
function of neuronal networks. Recent studies suggest microglia may also influence neuronal …

Glial βII spectrin contributes to paranode formation and maintenance

…, CR Tsai, MR Galiano, Y Liu, SD Benusa… - Journal of …, 2018 - Soc Neuroscience
Action potential conduction along myelinated axons depends on high densities of voltage-gated
Na + channels at the nodes of Ranvier. Flanking each node, paranodal junctions (…

The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair

…, DJ Stephenson, LA Hoeferlin, SD Benusa… - Science …, 2019 - science.org
The sphingolipid ceramide 1-phosphate (C1P) directly binds to and activates group IVA
cytosolic phospholipase A 2 (cPLA 2 α) to stimulate the production of eicosanoids. Because …

[PDF][PDF] Microglial heterogeneity: distinct cell types or differential functional adaptation

SD Benusa, NM George… - Neuroimmunology and …, 2020 - pdfs.semanticscholar.org
Microglia were first characterized by del Rio Hortega about 100 years ago but our
understanding of these cells has only gained traction in the last 20 years. We now recognize that …

Mechanisms Regulating Axon Initial Segment Stability

SD Benusa - 2018 - scholarscompass.vcu.edu
Axon initial segment (AIS) disruption has been described in a number of pathological
environments where neuroinflammation is a contributing factor; however, whether this disruption is …

[HTML][HTML] Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain

T Taetzsch, S Benusa, S Levesque, CL Mumaw… - Journal of …, 2019 - Springer
Background While NF-κB p50 function is impaired in central nervous system disease, aging
in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging…

HIPAA security compliance challenges: The case for small healthcare providers

JQ Chen, A Benusa - International Journal of Healthcare …, 2017 - Taylor & Francis
More than 60% of physicians in the US practice as small healthcare providers. The realm of
small healthcare providers includes dental offices, orthodontists, chiropractors, massage …

Impact of soil organic matter on Pu migration in five Lithuanian surface soils

L Kazakevičiūtė-Jakučiūnienė, R Druteikienė… - Journal of …, 2021 - Elsevier
… of elevated K d when 4 pH and 6 pH solutions were applied, but obtained K d values
were not … The K d of Pu for the fine fraction of peat soil with high organic matter content (67%) …