[HTML][HTML] Circulating microRNAs as biomarkers, therapeutic targets, and signaling molecules
SK Ajit - Sensors, 2012 - mdpi.com
Small noncoding microRNAs (miRNAs) are important regulators of post-transcriptional gene
regulation and have altered the prevailing view of a linear relationship between gene and …
regulation and have altered the prevailing view of a linear relationship between gene and …
Functional significance of macrophage-derived exosomes in inflammation and pain
Exosomes, secreted microvesicles transporting microRNAs (miRNAs), mRNAs, and proteins
through bodily fluids, facilitate intercellular communication and elicit immune responses. …
through bodily fluids, facilitate intercellular communication and elicit immune responses. …
Complex regional pain syndrome—phenotypic characteristics and potential biomarkers
F Birklein, SK Ajit, A Goebel, RSGM Perez… - Nature Reviews …, 2018 - nature.com
Complex regional pain syndrome (CRPS) is a pain condition that usually affects a single
limb, often following an injury. The underlying pathophysiology seems to be complex and …
limb, often following an injury. The underlying pathophysiology seems to be complex and …
Modulation of immune responses by exosomes derived from antigen-presenting cells
BB Shenoda, SK Ajit - Clinical Medicine Insights: Pathology, 2016 - journals.sagepub.com
Exosome-mediated signaling is important in mediating the inflammatory response. To exert
their biological or pathophysiological functions in the recipient cells, exosomes deliver a …
their biological or pathophysiological functions in the recipient cells, exosomes deliver a …
[HTML][HTML] MicroRNA modulation in complex regional pain syndrome
…, JE Barrett, RJ Schwartzman, SK Ajit - Journal of translational …, 2011 - Springer
Background Aberrant expression of small noncoding RNAs called microRNAs (miRNAs) is
a common feature of several human diseases. The objective of the study was to identify …
a common feature of several human diseases. The objective of the study was to identify …
[HTML][HTML] Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain
…, W Liu, GT Whiteside, TA Samad, JD Kennedy, SK Ajit - PloS one, 2011 - journals.plos.org
Neuropathic pain resulting from nerve lesions or dysfunction represents one of the most
challenging neurological diseases to treat. A better understanding of the molecular mechanisms …
challenging neurological diseases to treat. A better understanding of the molecular mechanisms …
MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability
RA Crozier, SK Ajit, EJ Kaftan… - Journal of …, 2007 - Soc Neuroscience
The recently identified Mas-related gene (Mrg) family of G-protein-coupled receptors is
expressed almost exclusively in dorsal root ganglion (DRG) neurons. The expression of one …
expressed almost exclusively in dorsal root ganglion (DRG) neurons. The expression of one …
[HTML][HTML] Differential RNA packaging into small extracellular vesicles by neurons and astrocytes
X Luo, R Jean-Toussaint, A Sacan, SK Ajit - Cell Communication and …, 2021 - Springer
Background Small extracellular vesicles (sEVs) mediate intercellular communication by
transferring RNA, proteins, and lipids to recipient cells. These cargo molecules are selectively …
transferring RNA, proteins, and lipids to recipient cells. These cargo molecules are selectively …
Therapeutic and prophylactic effects of macrophage-derived small extracellular vesicles in the attenuation of inflammatory pain
Small extracellular vesicles (sEVs) derived from antigen-presenting cells such as macrophages
can induce therapeutically relevant immune responses. Anti-inflammatory miRNAs are …
can induce therapeutically relevant immune responses. Anti-inflammatory miRNAs are …
Xist attenuates acute inflammatory response by female cells
Biological sex influences inflammatory response, as there is a greater incidence of acute
inflammation in men and chronic inflammation in women. Here, we report that acute …
inflammation in men and chronic inflammation in women. Here, we report that acute …