User profiles for Selene Lomoio
 | Selene LomoioTufts University School of Medicine Verified email at tufts.edu Cited by 416 |
Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease
E Aso, S Lomoio, I López‐González, L Joda… - Brain …, 2012 - Wiley Online Library
Double‐transgenic amyloid precursor protein/presenilin 1 (APP/PS1) mice express a chimeric
mouse/human APP bearing the Swedish mutation (Mo/HuAPP695swe) and a mutant …
mouse/human APP bearing the Swedish mutation (Mo/HuAPP695swe) and a mutant …
Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings
Axonal dystrophy, indicative of perturbed axonal transport, occurs early during Alzheimer’s
disease (AD) pathogenesis. Little is known about the mechanisms underlying this initial sign …
disease (AD) pathogenesis. Little is known about the mechanisms underlying this initial sign …
Pathophysiology of neurodegenerative diseases: an interplay among axonal transport failure, oxidative stress, and inflammation?
G Tesco, S Lomoio - Seminars in immunology, 2022 - Elsevier
Neurodegenerative diseases (NDs) are heterogeneous neurological disorders characterized
by a progressive loss of selected neuronal populations. A significant risk factor for most …
by a progressive loss of selected neuronal populations. A significant risk factor for most …
[HTML][HTML] BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD …
Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting
enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the …
enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the …
3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease
Several iPSC-derived three-dimensional (3D) cultures have been generated to model
Alzheimer’s disease (AD). While some AD-related phenotypes have been identified across these …
Alzheimer’s disease (AD). While some AD-related phenotypes have been identified across these …
Axonal abnormalities in cerebellar Purkinje cells of the Ts65Dn mouse
Ts65Dn mice are a genetic model for Down syndrome. Among others, these mice have
cerebellar pathology features which parallel those seen in Down syndrome patients. Both …
cerebellar pathology features which parallel those seen in Down syndrome patients. Both …
Functional and sustainable 3D human neural network models from pluripotent stem cells
Three-dimensional (3D) in vitro cell and tissue culture models, particularly for the central
nervous system, allow for the exploration of mechanisms of organ development, cellular …
nervous system, allow for the exploration of mechanisms of organ development, cellular …
[HTML][HTML] Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo
Neural cell adhesion molecules 1 (NCAM1) and 2 (NCAM2) belong to the cell adhesion
molecules of the immunoglobulin superfamily and have been shown to regulate formation, …
molecules of the immunoglobulin superfamily and have been shown to regulate formation, …
Dysfunction of the ubiquitin–proteasome system in the cerebellum of aging Ts65Dn mice
In the cerebellum of adult-aging Ts65Dn mice, a murine model of Down syndrome, Purkinje
cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have …
cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have …
Cerebellar amyloid-β plaques: disturbed cortical circuitry in AβPP/PS1 transgenic mice as a model of familial Alzheimer's disease
S Lomoio, I López-González, E Aso… - Journal of …, 2012 - content.iospress.com
Cerebellar amyloid-β (Aβ) deposition in the form of neuritic plaques and Purkinje cell loss
are common in certain pedigrees of familial Alzheimer's disease (FAD) mainly linked to PS1 …
are common in certain pedigrees of familial Alzheimer's disease (FAD) mainly linked to PS1 …