In the mammalian white matter, glycogen-derived lactate from astrocytes plays a critical role
in supporting axon function using the astrocyte-neuron lactate transfer shuttle (ANLTS) …

Oligodendrocytes make myelin and support axons metabolically with lactate. However, it is
unknown how glucose utilization and glycolysis are adapted to the different axonal energy …

We tested the hypothesis that glaucoma disrupts electrophysiological conduction properties
and axon function in optic nerve as a function of intraocular pressure (IOP) levels and age in …

The impact of aging on CNS white matter (WM) is of general interest because the global
effects of aging on myelinated nerve fibers are more complex and profound than those in …

Stroke incidence increases with age and this has been attributed to vascular factors. We show
here that CNS white matter (WM) is intrinsically more vulnerable to ischemic injury in older …

The importance of white matter (WM) injury to stroke pathology has been underestimated in
experimental animal models and this may have contributed to the failure to translate …

Understanding how epigenetics influences the process and progress of a stroke could yield
new targets and therapeutics for use in the clinic. Experimental evidence suggests that …

Glutamate is the main excitatory transmitter in the brain, while ATP represents the most
important energy currency in any living cell. Yet, these chemicals play an important role in both …

Drugs that inhibit specific histone deacetylase (HDAC) activities have enormous potential in
preventing the consequences of acute injury to the nervous system and in allaying …

Cognitive deficits after aneurysmal subarachnoid hemorrhage (SAH) are common and disabling.
Patients who experience delayed deterioration associated with vasospasm are likely to …