The ability to culture and maintain postnatal mouse hippocampal and cortical neurons is
highly advantageous, particularly for studies on genetically engineered mouse models. Here …

Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum
of their possible activation states is not well understood. We derived co-regulated gene …

The association of p120 catenin (p120) with the juxtamembrane domain (JMD) of the cadherin
cytoplasmic tail is critical for the surface stability of cadherin-catenin cell-cell adhesion …

Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2
deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a …

The generation of reactive oxygen species (ROS) in cells stimulated with growth factors
requires the activation of phosphatidylinositol 3-kinase (PI3K) and the Rac protein. We report …

Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative
diseases, so understanding oligodendrocyte activation states would shed light on disease …

Complex diseases are characterized by spatiotemporal cellular and molecular changes that
may be difficult to comprehensively capture. However, understanding the spatiotemporal …

TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of
Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus …

Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and
neuronal cell death, yet the cellular pathways that underlie these processes remain largely …

Tau has become an attractive alternative target for passive immunotherapy efforts for
Alzheimer’s disease (AD). The anatomical distribution and extent of tau pathology correlate with …