Perineurial defect and peripheral opioid analgesia in inflammation
I Antonijevic, SA Mousa, M Schafer… - Journal of …, 1995 - Soc Neuroscience
Opioid receptors have been demonstrated on sensory nerves in both inflamed and normal
subcutaneous tissue but locally applied opioid agonists produce analgesia in inflamed tissue …
subcutaneous tissue but locally applied opioid agonists produce analgesia in inflamed tissue …
Opioid peptide–expressing leukocytes: Identification, recruitment, and simultaneously Increasing Inhibition of inflammatory pain
…, A Brack, H Machelska, SA Mousa… - The Journal of the …, 2001 - pubs.asahq.org
Background Inflammatory pain can be effectively controlled by an interaction of opioid receptors
on peripheral sensory nerve terminals with opioid peptides released from immune cells …
on peripheral sensory nerve terminals with opioid peptides released from immune cells …
β-Endorphin-containing memory-cells and μ-opioid receptors undergo transport to peripheral inflamed tissue
Immunocyte-derived β-endorphin can activate peripheral opioid receptors on sensory neurons
to inhibit pain within inflamed tissue. This study examined μ-opioid receptors (MOR) on …
to inhibit pain within inflamed tissue. This study examined μ-opioid receptors (MOR) on …
Subcellular pathways of β-endorphin synthesis, processing, and release from immunocytes in inflammatory pain
SA Mousa, M Shakibaei, N Sitte, M Schäfer… - …, 2004 - academic.oup.com
… *Address all correspondence and requests for reprints to: Shaaban A. Mousa, Ph.D., Klinik
für Anaesthesiologie und Operative Intensivmedizin, Charité-Universitätsmedizin Berlin, …
für Anaesthesiologie und Operative Intensivmedizin, Charité-Universitätsmedizin Berlin, …
μ-opioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain
J Endres-Becker, PA Heppenstall, SA Mousa… - Molecular …, 2007 - ASPET
Current therapy for inflammatory pain includes the peripheral application of opioid receptor
agonists. Activation of opioid receptors modulates voltage-gated ion channels, but it is …
agonists. Activation of opioid receptors modulates voltage-gated ion channels, but it is …
Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue
W Binder, SA Mousa, N Sitte, M Kaiser… - European Journal of …, 2004 - Wiley Online Library
Stress induces analgesia by mechanisms within and outside the brain. Here we show that
the sympathetic nervous system is an essential trigger of intrinsic opioid analgesia within …
the sympathetic nervous system is an essential trigger of intrinsic opioid analgesia within …
Pain control by CXCR2 ligands through Ca2+ ‐regulated release of opioid peptides from polymorphonuclear cells
HL Rittner, D Labuz, M Schaefer, SA Mousa… - The FASEB …, 2006 - Wiley Online Library
Leukocytes counteract inflammatory pain by releasing opioid peptides, which bind to opioid
receptors on peripheral sensory neurons. In the early phase of inflammation, …
receptors on peripheral sensory neurons. In the early phase of inflammation, …
Relative contribution of peripheral versus central opioid receptors to antinociception
Opioid effects are mediated by central and peripheral opioid receptors. Here we examine the
relative contribution of each receptor population to antinociception elicited by systemically …
relative contribution of each receptor population to antinociception elicited by systemically …
Different mechanisms of intrinsic pain inhibition in early and late inflammation
H Machelska, JK Schopohl, SA Mousa, D Labuz… - Journal of …, 2003 - Elsevier
Neuroimmune interactions control pain through activation of opioid receptors on sensory
nerves by immune-derived opioid peptides. Here we evaluate mechanisms of intrinsic pain …
nerves by immune-derived opioid peptides. Here we evaluate mechanisms of intrinsic pain …
[HTML][HTML] Immune cell–derived opioids protect against neuropathic pain in mice
…, A Schreiter, HL Rittner, SA Mousa… - The Journal of …, 2009 - Am Soc Clin Investig
The analgesic effects of leukocyte-derived opioids have been exclusively demonstrated for
somatic inflammatory pain, for example, the pain associated with surgery and arthritis. …
somatic inflammatory pain, for example, the pain associated with surgery and arthritis. …