Perineurial defect and peripheral opioid analgesia in inflammation

I Antonijevic, SA Mousa, M Schafer… - Journal of …, 1995 - Soc Neuroscience
Opioid receptors have been demonstrated on sensory nerves in both inflamed and normal
subcutaneous tissue but locally applied opioid agonists produce analgesia in inflamed tissue …

Opioid peptide–expressing leukocytes: Identification, recruitment, and simultaneously Increasing Inhibition of inflammatory pain

…, A Brack, H Machelska, SA Mousa… - The Journal of the …, 2001 - pubs.asahq.org
Background Inflammatory pain can be effectively controlled by an interaction of opioid receptors
on peripheral sensory nerve terminals with opioid peptides released from immune cells …

β-Endorphin-containing memory-cells and μ-opioid receptors undergo transport to peripheral inflamed tissue

SA Mousa, Q Zhang, N Sitte, RR Ji, C Stein - Journal of neuroimmunology, 2001 - Elsevier
Immunocyte-derived β-endorphin can activate peripheral opioid receptors on sensory neurons
to inhibit pain within inflamed tissue. This study examined μ-opioid receptors (MOR) on …

Subcellular pathways of β-endorphin synthesis, processing, and release from immunocytes in inflammatory pain

SA Mousa, M Shakibaei, N Sitte, M Schäfer… - …, 2004 - academic.oup.com
… *Address all correspondence and requests for reprints to: Shaaban A. Mousa, Ph.D., Klinik
für Anaesthesiologie und Operative Intensivmedizin, Charité-Universitätsmedizin Berlin, …

μ-opioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain

J Endres-Becker, PA Heppenstall, SA Mousa… - Molecular …, 2007 - ASPET
Current therapy for inflammatory pain includes the peripheral application of opioid receptor
agonists. Activation of opioid receptors modulates voltage-gated ion channels, but it is …

Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue

W Binder, SA Mousa, N Sitte, M Kaiser… - European Journal of …, 2004 - Wiley Online Library
Stress induces analgesia by mechanisms within and outside the brain. Here we show that
the sympathetic nervous system is an essential trigger of intrinsic opioid analgesia within …

Pain control by CXCR2 ligands through Ca2+ ‐regulated release of opioid peptides from polymorphonuclear cells

HL Rittner, D Labuz, M Schaefer, SA Mousa… - The FASEB …, 2006 - Wiley Online Library
Leukocytes counteract inflammatory pain by releasing opioid peptides, which bind to opioid
receptors on peripheral sensory neurons. In the early phase of inflammation, …

Relative contribution of peripheral versus central opioid receptors to antinociception

D Labuz, SA Mousa, M Schäfer, C Stein, H Machelska - Brain research, 2007 - Elsevier
Opioid effects are mediated by central and peripheral opioid receptors. Here we examine the
relative contribution of each receptor population to antinociception elicited by systemically …

Different mechanisms of intrinsic pain inhibition in early and late inflammation

H Machelska, JK Schopohl, SA Mousa, D Labuz… - Journal of …, 2003 - Elsevier
Neuroimmune interactions control pain through activation of opioid receptors on sensory
nerves by immune-derived opioid peptides. Here we evaluate mechanisms of intrinsic pain …

[HTML][HTML] Immune cell–derived opioids protect against neuropathic pain in mice

…, A Schreiter, HL Rittner, SA Mousa… - The Journal of …, 2009 - Am Soc Clin Investig
The analgesic effects of leukocyte-derived opioids have been exclusively demonstrated for
somatic inflammatory pain, for example, the pain associated with surgery and arthritis. …