LONG-TERM potentiation (LTP) is a synaptic mechanism thought to be involved in learning
and memory 1 . Long-term depression (LTD), an activity-dependent decrease in synaptic …

The stability of c-Myc is regulated by multiple Ras effector pathways. Phosphorylation at Ser
62 stabilizes c-Myc, whereas subsequent phosphorylation at Thr 58 is required for its …

The control of biological events requires strict regulation using complex protein phosphorylation
and dephosphorylation strategies. The bulk of serine-threonine dephosphorylations are …

Stimulation of β 2 -adrenergic receptors on the cell surface by adrenaline or noradrenaline
leads to alterations in the metabolism, excitability, differentiation and growth of many cell types…

Proprotein convertase subtilisin kexin type 9 (PCSK9) lowers the abundance of surface low-density
lipoprotein (LDL) receptor through an undefined mechanism. The structure of human …

Results To examine the kinetics of CAMP induction, we performed run-on transcription assays
using PC12 and 3T3 cell clones stably transfected with a somatostatin reporter gene. In …

The growth arrest and DNA damage-inducible protein, GADD34, associates with protein
phosphatase 1 (PP1) and promotes in vitro dephosphorylation of the α subunit of eukaryotic …

Long-term potentiation (LTP) at the Schaffer collateral–CA1 synapse involves interacting
signaling components, including calcium (Ca 2+ )/calmodulin–dependent protein kinase II (…

Protein phosphorylation is now well recognized as a mechanism widely uti lized by plant
and animal cells to regulate their functions. The covalent mod ification of regulatory proteins …

The growth arrest and DNA damage-inducible protein, GADD34, was identified by its interaction
with human inhibitor 1 (I-1), a protein kinase A (PKA)-activated inhibitor of type 1 protein …