Electrophiles and reactive oxygen species have been implicated in the pathogenesis of
many diseases. Transcription factor Nrf2 was recently identified as a general regulator of one …

Transport system x c − found in plasma membrane of cultured mammalian cells is an
exchange agency for anionic amino acids with high specificity for anionic form of cystine and …

It is found that both the inward and outward transport of cystine and glutamate through the
plasma membrane of cultured human fibroblasts is mediated mostly by a single transport …

In mammalian cultured cells, the cystine/glutamate exchange transport mediated by system
x c − is important to maintain intracellular GSH levels. System x c − consists of two protein …

Glutathione levels in neurons and gllal cells were investigated in a neuronal‐glial coculture
and in separate cultures. Brain cell suspensions obtained from cerebral hemispheres of fetal …

Cystine/glutamate transporter, designated as system x – c , mediates cystine entry in exchange
for intracellular glutamate in mammalian cells. This transporter consists of two protein …

The basic concepts on the transport of amino acids across mammalian cell membranes have
been developed primarily by Christensen and co-workers using Ehrlich ascites tumor cells […

Abstract System x c − was recently described as the most upstream node in a novel form of
regulated necrotic cell death, called ferroptosis. In this context, the small molecule erastin …

The mechanism of the growth-promoting action of 2-mercaptoethanol on mouse lymphoma
L1210 cells in vitro has been studied. The normal line of L1210 is deficient in its capacity to …

GSH is the major antioxidant and detoxifier of xenobiotics in mammalian cells. A strong decrease
of intracellular GSH has been frequently linked to pathological conditions like ischemia/…