User profiles for Stacy Gelhaus Wendell

Stacy Gelhaus Wendell

Associate Professor, University of Pittsburgh
Verified email at pitt.edu
Cited by 3765

[PDF][PDF] Early TCR signaling induces rapid aerobic glycolysis enabling distinct acute T cell effector functions

…, S Salvatore, H Bae, J Xie, HA Young, SG Wendell… - Cell reports, 2018 - cell.com
To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process
common to highly proliferative cells in which glucose is fermented into lactate rather than …

Fatty acids, inflammation, and asthma

SG Wendell, C Baffi, F Holguin - Journal of Allergy and Clinical Immunology, 2014 - Elsevier
Fatty acids and consequently diet play an essential role in the formation of inflammatory
mediators involved in the pathogenesis of asthma. Because intake variations of omega-6 (n-6) …

Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids

…, BA Freeman, SG Wendell - Annual review of …, 2014 - annualreviews.org
Unsaturated fatty acids are metabolized to reactive products that can act as pro- or anti-inflammatory
signaling mediators. Electrophilic fatty acid species, including nitro- and oxo-…

ERK1/2 activation in preexisting oligodendrocytes of adult mice drives new myelin synthesis and enhanced CNS function

…, K Urbanek, L Torres, SG Wendell… - Journal of …, 2016 - Soc Neuroscience
Growing evidence shows that mechanisms controlling CNS plasticity extend beyond the
synapse and that alterations in myelin can modify conduction velocity, leading to changes in …

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes

…, MT Gladwin, BA Freeman, SG Wendell - Free Radical Biology …, 2015 - Elsevier
A gap in our understanding of the beneficial systemic responses to dietary constituents
nitrate (NO 3 − ), nitrite (NO 2 − ) and conjugated linoleic acid (cLA) is the identification of the …

G protein–coupled receptors in asthma therapy: pharmacology and drug action

SG Wendell, H Fan, C Zhang - Pharmacological reviews, 2020 - ASPET
Asthma is a heterogeneous inflammatory disease of the airways that is associated with
airway hyperresponsiveness and airflow limitation. Although asthma was once simply …

Nitro-fatty acid formation and metabolism

…, G Bonacci, M Fazzari, SR Salvatore, SG Wendell - Nitric Oxide, 2018 - Elsevier
Nitro-fatty acids (NO 2 -FA) are pleiotropic modulators of redox signaling pathways. Their
effects on inflammatory signaling have been studied in great detail in cell, animal and clinical …

Conjugated linoleic acid modulates clinical responses to oral nitrite and nitrate

KS Hughan, SG Wendell, M Delmastro-Greenwood… - …, 2017 - Am Heart Assoc
Dietary NO 3 − (nitrate) and NO 2 − (nitrite) support NO (nitric oxide) generation and
downstream vascular signaling responses. These nitrogen oxides also generate secondary …

15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways

…, Y Gao, IA Blair, BA Freeman, SG Wendell - Chemico-biological …, 2015 - Elsevier
Bioactive lipids govern cellular homeostasis and pathogenic inflammatory processes. Current
dogma holds that bioactive lipids, such as prostaglandins and lipoxins, are inactivated by …

[HTML][HTML] 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids

SG Wendell, F Golin-Bisello, S Wenzel… - Journal of Biological …, 2015 - ASBMB
15-Hydroxyprostaglandin dehydrogenase (15PGDH) is the primary enzyme catalyzing the
conversion of hydroxylated arachidonic acid species to their corresponding oxidized …