Dendrites of cortical pyramidal neurons contain intermingled excitatory and inhibitory
synapses. We studied the local mechanisms that regulate the formation and distribution of …

NMDA receptors (NMDARs) play a critical role in excitatory synaptic transmission, plasticity
and in several forms of learning and memory. In addition, NMDAR dysfunction is believed to …

Protein phosphorylation is an essential step for the expression of long-term potentiation (LTP),
a long-lasting, activity-dependent strengthening of synaptic transmission widely regarded …

The cerebellum, traditionally associated with motor coordination and balance, also plays a
crucial role in various aspects of higher-order function and dysfunction. Emerging research …

Synaptic connections between hippocampal mossy fibers (MFs) and CA3 pyramidal neurons
are essential for contextual memory encoding, but the molecular mechanisms regulating …

Dendritic spines are dynamic, actin-rich protrusions in neurons that undergo remodeling during
neuronal development and activity-dependent plasticity within the central nervous system…

Transcription factors have a pivotal role in synaptic plasticity and the associated modification
of neuronal networks required for memory formation and consolidation. The nuclear …

Mossy cells (MCs) of the dentate gyrus are key components of an excitatory associative
circuit established by reciprocal connections with dentate granule cells (GCs). MCs are …

Increase in dopamine output on corticolimbic structures, such as medial prefrontal cortex (mPFC)
and nucleus accumbens, has been related to reward effects associated with palatable …

Long-term potentiation and depression of NMDA receptor-mediated synaptic transmission (NMDAR
LTP/LTD) can significantly impact synapse function and information transfer in …