User profiles for Stephen Freedman
Stephen B FreedmanUniversity of Calgary Verified email at albertahealthservices.ca Cited by 13778 |
BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain: implications for Alzheimer's disease therapeutics
…, DG Branstetter, KS Chen, S Freedman… - Human molecular …, 2001 - academic.oup.com
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by accumulation of
amyloid plaques and neurofibrillary tangles in the brain. The major components of plaque, β…
amyloid plaques and neurofibrillary tangles in the brain. The major components of plaque, β…
A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease
…, A Justice, L McConlogue, D Games, SB Freedman… - Nature, 2000 - nature.com
Mice that overexpress the human mutant amyloid precursor protein (hAPP) show learning
deficits, but the apparent lack of a relationship between these deficits and the progressive β-…
deficits, but the apparent lack of a relationship between these deficits and the progressive β-…
A living WHO guideline on drugs for covid-19
This living guideline by Arnav Agarwal and colleagues (BMJ 2020; 370: m3379, doi: 10.1136/bmj.
m3379) was last updated on 22 April 2022, but the infographic contained two dosing …
m3379) was last updated on 22 April 2022, but the infographic contained two dosing …
Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED
Importance Approximately one-third of children experiencing acute concussion experience
ongoing somatic, cognitive, and psychological or behavioral symptoms, referred to as …
ongoing somatic, cognitive, and psychological or behavioral symptoms, referred to as …
A living WHO guideline on drugs for covid-19
Updates This is the thirteenth version (twelfth update) of the living guideline, replacing earlier
versions (available as data supplements). New recommendations will be published as …
versions (available as data supplements). New recommendations will be published as …
[HTML][HTML] Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice
…, EF Brigham, KS Chen, SB Freedman… - Journal of Biological …, 2007 - ASBMB
The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates
processing of amyloid precursor protein (APP) into amyloid β (Aβ) peptide, the major …
processing of amyloid precursor protein (APP) into amyloid β (Aβ) peptide, the major …
[HTML][HTML] Oral ondansetron for gastroenteritis in a pediatric emergency department
SB Freedman, M Adler, R Seshadri… - New England Journal …, 2006 - Mass Medical Soc
Background Vomiting limits the success of oral rehydration in children with gastroenteritis. We
conducted a double-blind trial to determine whether a single oral dose of ondansetron, an …
conducted a double-blind trial to determine whether a single oral dose of ondansetron, an …
Association between early participation in physical activity following acute concussion and persistent postconcussive symptoms in children and adolescents
…, M Aglipay, F Momoli, WP Meehan, SB Freedman… - Jama, 2016 - jamanetwork.com
Importance Although concussion treatment guidelines advocate rest in the immediate postinjury
period until symptoms resolve, no clear evidence has determined that avoiding physical …
period until symptoms resolve, no clear evidence has determined that avoiding physical …
Expression and pharmacological characterization of the human D3 dopamine receptor.
SB Freedman, S Patel, R Marwood, F Emms… - … of Pharmacology and …, 1994 - ASPET
Binding of dopamine receptor ligands to human D2 and D3 receptors was characterized in
Chinese hamster ovary (CHO) cells using the dopamine D2 receptor antagonist [125I] …
Chinese hamster ovary (CHO) cells using the dopamine D2 receptor antagonist [125I] …
Pediatric myocarditis: emergency department clinical findings and diagnostic evaluation
SB Freedman, JK Haladyn, A Floh, JA Kirsh… - …, 2007 - publications.aap.org
OBJECTIVE. The goal was to determine, in children with myocarditis, the frequency of various
presenting symptoms and the sensitivity of clinical and laboratory investigations routinely …
presenting symptoms and the sensitivity of clinical and laboratory investigations routinely …