User profiles for Stephen Freedman

Stephen B Freedman

University of Calgary
Verified email at albertahealthservices.ca
Cited by 13778

BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain: implications for Alzheimer's disease therapeutics

…, DG Branstetter, KS Chen, S Freedman… - Human molecular …, 2001 - academic.oup.com
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by accumulation of
amyloid plaques and neurofibrillary tangles in the brain. The major components of plaque, β…

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

…, A Justice, L McConlogue, D Games, SB Freedman… - Nature, 2000 - nature.com
Mice that overexpress the human mutant amyloid precursor protein (hAPP) show learning
deficits, but the apparent lack of a relationship between these deficits and the progressive β-…

A living WHO guideline on drugs for covid-19

…, D Chanda, VQ Dat, A De Sutter, B Du, S Freedman… - 2022 - scholar.sun.ac.za
This living guideline by Arnav Agarwal and colleagues (BMJ 2020; 370: m3379, doi: 10.1136/bmj.
m3379) was last updated on 22 April 2022, but the infographic contained two dosing …

Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED

R Zemek, N Barrowman, SB Freedman, J Gravel… - Jama, 2016 - jamanetwork.com
Importance Approximately one-third of children experiencing acute concussion experience
ongoing somatic, cognitive, and psychological or behavioral symptoms, referred to as …

A living WHO guideline on drugs for covid-19

…, D Chanda, VQ Dat, A De Sutter, B Du, S Freedman… - bmj, 2020 - bmj.com
Updates This is the thirteenth version (twelfth update) of the living guideline, replacing earlier
versions (available as data supplements). New recommendations will be published as …

[HTML][HTML] Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice

…, EF Brigham, KS Chen, SB Freedman… - Journal of Biological …, 2007 - ASBMB
The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates
processing of amyloid precursor protein (APP) into amyloid β (Aβ) peptide, the major …

[HTML][HTML] Oral ondansetron for gastroenteritis in a pediatric emergency department

SB Freedman, M Adler, R Seshadri… - New England Journal …, 2006 - Mass Medical Soc
Background Vomiting limits the success of oral rehydration in children with gastroenteritis. We
conducted a double-blind trial to determine whether a single oral dose of ondansetron, an …

Association between early participation in physical activity following acute concussion and persistent postconcussive symptoms in children and adolescents

…, M Aglipay, F Momoli, WP Meehan, SB Freedman… - Jama, 2016 - jamanetwork.com
Importance Although concussion treatment guidelines advocate rest in the immediate postinjury
period until symptoms resolve, no clear evidence has determined that avoiding physical …

Expression and pharmacological characterization of the human D3 dopamine receptor.

SB Freedman, S Patel, R Marwood, F Emms… - … of Pharmacology and …, 1994 - ASPET
Binding of dopamine receptor ligands to human D2 and D3 receptors was characterized in
Chinese hamster ovary (CHO) cells using the dopamine D2 receptor antagonist [125I] …

Pediatric myocarditis: emergency department clinical findings and diagnostic evaluation

SB Freedman, JK Haladyn, A Floh, JA Kirsh… - …, 2007 - publications.aap.org
OBJECTIVE. The goal was to determine, in children with myocarditis, the frequency of various
presenting symptoms and the sensitivity of clinical and laboratory investigations routinely …