Fig. 1. The mechanism of heat-shock protein 70 (HSP70) production following focal ischemia
in the brain. Ischemia produces denatured proteins within cells. The denatured proteins …

Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase
B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and …

Revised Manuscript Received October 9, 1992 abstract: The soluble mammalian lactose-binding
lectins L-14-I and L-29 are both secreted and bind to oligosaccharides on laminin, a …

Neurotrophins and their receptors modulate multiple signalling pathways to regulate
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity. …

Oligomeric forms of amyloid-β (Aβ) are thought to play a causal role in Alzheimer's disease (AD),
and the p75 neurotrophin receptor (p75 NTR ) has been implicated in Aβ-induced …

In investigating the role of metal ions in the pathogenesis of Huntington's disease, we
examined the effects of clioquinol, a metal-binding compound currently in clinical trials for …

L-14, a dimeric lactose-binding lectin with subunits of 14 kD, is expressed in a wide range of
vertebrate tissues. Several functions have been postulated for this lectin, but definitive …

Studies showing that neurotrophin binding to p75 NTR can promote cell survival in the
absence of Trk (tropomyosin-related kinase) receptors, together with recent structural data …

Rett syndrome (RTT) results from loss-of-function mutations in the gene encoding the methyl-CpG-binding
protein 2 (MeCP2) and is characterized by abnormal motor, respiratory and …

Loss of neurotrophic support in the striatum caused by reduced brain-derived neurotrophic
factor (BDNF) levels plays a critical role in Huntington's disease (HD) pathogenesis. BDNF …