G protein-coupled receptors (GPCRs) are seven transmembrane proteins that form the largest
single family of integral membrane receptors. GPCRs transduce information provided by …

GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …

G-protein-coupled receptors (GPCRs) represent a large family of proteins that transduce
extracellular signals to the interior of cells. Signalling through these receptors rapidly …

β-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G
protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by …

βarrestins mediate the desensitization of the β 2 -adrenergic receptor (β 2 AR) and many
other G protein-coupled receptors (GPCRs). Additionally, βarrestins initiate the endocytosis of …

The classical paradigm for G protein-coupled receptor (GPCR) signal transduction involves
the agonist-dependent interaction of GPCRs with heterotrimeric G proteins at the plasma …

The G protein-coupled μ-opioid receptor (μOR) mediates the physiological effects of
endogenous opioid peptides as well as the structurally distinct opioid alkaloids morphine and …

The process of agonist-promoted internalization (sequestration) of G protein-coupled receptors
(GPCRs) is intimately linked to the regulation of GPCR responsiveness. Following agonist…

G protein-coupled receptors (GPCR) represent the single most important drug targets for
medical therapy, and information from genome sequencing and genomic data bases has …

… exhibited matching pharmacologies (Ferguson and Caron, … concentrations of antagonist
(Ferguson and Caron, … receptor in endocytic vesicles (Ferguson and Caron, unpublished …