User profiles for Stephen S. G. Ferguson
Stephen SG FergusonUniversity of Ottawa Brain and Mind Institute, Department of Cellular Medicine Verified email at uottawa.ca Cited by 23160 |
Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling
SSG Ferguson - Pharmacological reviews, 2001 - ASPET
G protein-coupled receptors (GPCRs) are seven transmembrane proteins that form the largest
single family of integral membrane receptors. GPCRs transduce information provided by …
single family of integral membrane receptors. GPCRs transduce information provided by …
Regulation of GPCR activity, trafficking and localization by GPCR‐interacting proteins
…, H Dunn, SSG Ferguson - British journal of …, 2012 - Wiley Online Library
GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
SSG Ferguson, LS Barak, J Zhang… - Canadian journal of …, 1996 - cdnsciencepub.com
G-protein-coupled receptors (GPCRs) represent a large family of proteins that transduce
extracellular signals to the interior of cells. Signalling through these receptors rapidly …
extracellular signals to the interior of cells. Signalling through these receptors rapidly …
Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
SSG Ferguson, WE Downey III, AM Colapietro… - Science, 1996 - science.org
β-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G
protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by …
protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by …
The β2-adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis
…, J Zhang, JA Holt, SSG Ferguson… - Proceedings of the …, 1999 - National Acad Sciences
βarrestins mediate the desensitization of the β 2 -adrenergic receptor (β 2 AR) and many
other G protein-coupled receptors (GPCRs). Additionally, βarrestins initiate the endocytosis of …
other G protein-coupled receptors (GPCRs). Additionally, βarrestins initiate the endocytosis of …
[HTML][HTML] Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase
…, S Ahn, GJ Della Rocca, SSG Ferguson… - Journal of Biological …, 1998 - ASBMB
The classical paradigm for G protein-coupled receptor (GPCR) signal transduction involves
the agonist-dependent interaction of GPCRs with heterotrimeric G proteins at the plasma …
the agonist-dependent interaction of GPCRs with heterotrimeric G proteins at the plasma …
Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness
J Zhang, SSG Ferguson, LS Barak… - Proceedings of the …, 1998 - National Acad Sciences
The G protein-coupled μ-opioid receptor (μOR) mediates the physiological effects of
endogenous opioid peptides as well as the structurally distinct opioid alkaloids morphine and …
endogenous opioid peptides as well as the structurally distinct opioid alkaloids morphine and …
[HTML][HTML] Dynamin and β-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization
J Zhang, SSG Ferguson, LS Barak, L Ménard… - Journal of Biological …, 1996 - ASBMB
The process of agonist-promoted internalization (sequestration) of G protein-coupled receptors
(GPCRs) is intimately linked to the regulation of GPCR responsiveness. Following agonist…
(GPCRs) is intimately linked to the regulation of GPCR responsiveness. Following agonist…
[HTML][HTML] A β-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation
LS Barak, SSG Ferguson, J Zhang… - Journal of Biological …, 1997 - ASBMB
G protein-coupled receptors (GPCR) represent the single most important drug targets for
medical therapy, and information from genome sequencing and genomic data bases has …
medical therapy, and information from genome sequencing and genomic data bases has …
Molecular mechanisms of G protein-coupled receptor desensitization and resensitization
SSG Ferguson, J Zhang, LS Barakt, MG Caron - Life sciences, 1998 - Elsevier
… exhibited matching pharmacologies (Ferguson and Caron, … concentrations of antagonist
(Ferguson and Caron, … receptor in endocytic vesicles (Ferguson and Caron, unpublished …
(Ferguson and Caron, … receptor in endocytic vesicles (Ferguson and Caron, unpublished …