Large-conductance calcium-activated (maxi-K, BK) potassium channels are widely distributed
in the brain. Maxi-K channels function as neuronal calcium sensors and contribute to the …

During ischemic stroke, neurons at risk are exposed to pathologically high levels of intracellular
calcium (Ca++), initiating a fatal biochemical cascade. To protect these neurons, we …

To determine if the number of targeting signals affects the transport of proteins into the nucleus,
Xenopus oocytes were injected with colloidal gold particles, ranging in diameter from 20 …

Large-conductance calcium-activated potassium channels (maxi-K channels) have an
essential role in the control of excitability and secretion. Only one gene Slo is known to encode …

Potassium channels have been identified as targets for a large number of therapeutic
indications. The ability to use a high-throughput functional assay for the detection and …

3-Aryl-3-fluorooxindoles can be efficiently synthesized in two steps by the addition of an aryl
Grignard to an isatin, followed by treatment with DAST. Oxindole 1 (BMS-204352; MaxiPost…

In the present study, various sized gold particles coated with tRNA, 5S RNA, or poly(A) were
used to localize and characterize the pathways for RNA translocation to the cytoplasm. RNA-…

A human homolog of the large-conductance calcium-activated potassium (BK) channel β
subunit (hSloβ) was cloned, and its effects on a human BK channel (hSlo) phenotype are …

Through expression of the cloned mouse (mSlo) or human (hSlo) large-conductance (BK)
Ca(2+)-activated K+ channel in Xenopus laevis oocytes and HEK 293 cells, we characterized …

Publisher Summary This chapter summarizes the current status of pharmacological
development targeted at an important class of K + channel, the BK channel. BK Channels are a …