[HTML][HTML] Rescue of retinal degeneration by intravitreally injected adult bone marrow–derived lineage-negative hematopoietic stem cells
…, K Kinder, SK Moreno, S Nusinowitz… - The Journal of …, 2004 - Am Soc Clin Investig
Inherited retinal degenerations afflict 1 in 3,500 individuals and are a heterogeneous group
of diseases that result in profound vision loss, usually the result of retinal neuronal apoptosis…
of diseases that result in profound vision loss, usually the result of retinal neuronal apoptosis…
[HTML][HTML] Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases
purpose. Excessive accumulation of lipofuscin is observed in numerous degenerative retinal
diseases. A toxic vitamin A–based fluorophore (A2E) present within lipofuscin has been …
diseases. A toxic vitamin A–based fluorophore (A2E) present within lipofuscin has been …
Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration
RA Radu, NL Mata, S Nusinowitz… - Proceedings of the …, 2003 - National Acad Sciences
Recessive Stargardt's macular degeneration is an inherited blinding disease of children
caused by mutations in the ABCR gene. The primary pathologic defect in Stargardt's disease is …
caused by mutations in the ABCR gene. The primary pathologic defect in Stargardt's disease is …
[HTML][HTML] Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis
J Pang, B Chang, A Kumar, S Nusinowitz… - Molecular Therapy, 2006 - cell.com
Retinal pigment epithelium-specific protein 65 kDa (RPE65) is a protein responsible for
isomerization of all-trans-retinaldehyde to its photoactive 11-cis-retinaldehyde and is essential …
isomerization of all-trans-retinaldehyde to its photoactive 11-cis-retinaldehyde and is essential …
[PDF][PDF] Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA)
…, S Kaushal, WW Hauswirth, S Nusinowitz… - Mol Vis, 2005 - molvis.org
Purpose: To report the phenotype and characterization of a new, naturally occurring mouse
model of hereditary retinal degeneration (rd12). Methods: The retinal phenotype of rd12 mice …
model of hereditary retinal degeneration (rd12). Methods: The retinal phenotype of rd12 mice …
A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse
…, PM Nishina, S Nusinowitz… - Proceedings of the …, 2000 - National Acad Sciences
The rd7 mouse, an animal model for hereditary retinal degeneration, has some characteristics
similar to human flecked retinal disorders. Here we report the identification of a deletion in …
similar to human flecked retinal disorders. Here we report the identification of a deletion in …
[HTML][HTML] Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation
…, J Hu, JH Peng, M Lloyd, S Nusinowitz… - … & visual science, 2008 - iovs.arvojournals.org
purpose. Dietary supplementation with vitamin A is sometimes prescribed as a treatment for
retinitis pigmentosa, a group of inherited retinal degenerations that cause progressive …
retinitis pigmentosa, a group of inherited retinal degenerations that cause progressive …
[HTML][HTML] Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure
…, OV Savinova, NL Hawes, A Zabaleta, S Nusinowitz… - BMC genetics, 2001 - Springer
Background Glaucoma is a blinding disease usually associated with high intraocular pressure
(IOP). In some families, abnormal anterior segment development contributes to glaucoma. …
(IOP). In some families, abnormal anterior segment development contributes to glaucoma. …
[HTML][HTML] Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2
…, P Atmaca-Sonmez, S Nusinowitz… - … & visual science, 2006 - iovs.arvojournals.org
purpose. To report a novel mouse model of achromatopsia with a cpfl3 mutation found in
the ALS/LtJ strain. methods. The effects of a cpfl3 mutation were documented using fundus …
the ALS/LtJ strain. methods. The effects of a cpfl3 mutation were documented using fundus …
Mouse model of subretinal neovascularization with choroidal anastomosis
…, NL Hawes, M Friedlander, S Nusinowitz… - Retina, 2003 - journals.lww.com
Purpose To characterize the phenotype and report a reliable genetic model of retinal angiogenesis
and subretinal neovascularization in the mouse. Methods The mouse phenotype was …
and subretinal neovascularization in the mouse. Methods The mouse phenotype was …