Although cocaine binds to several sites in the brain, the biochemical receptor mechanism or
mechanisms associated with its dependence producing properties are unknown. It is shown …

Squirrel monkeys pressed a lever at high rates under a second-order schedule of
reinforcement in which lever pressing produced a brief visual stimulus that was occasionally …

The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …

There is evidence for strong functional antagonistic interactions between adenosine A 2A
receptors (A 2A Rs) and dopamine D 2 receptors (D 2 Rs). Although a close physical …

The abuse of psychoactive ‘bath salts’ containing cathinones such as 3, 4-methylenedioxypyrovalerone
(MDPV) is a growing public health concern, yet little is known about their …

The physiological meaning of the coexpression of adenosine A2A receptors and group I
metabotropic glutamate receptors in γ- aminobutyric acid (GABA)ergic striatal neurons is …

Many attempts to obtain reliable self-administration behavior by laboratory animals with
delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been …

Aim To review briefly the methods, assumptions, models, accomplishments, drawbacks and
future directions of research using drug self‐administration in animals and humans. …

An increase in the extracellular concentration of dopamine in the nucleus accumbens (NAc)
is believed to be one of the main mechanisms involved in the rewarding and motor-…

This review examines the development of cannabinoid CB 1 receptor antagonists as a new
class of therapeutic agents for drug addiction. Abused drugs [alcohol, opiates, Δ 9 -…