Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

SC Chua Jr, WK Chung, XS Wu-Peng, Y Zhang, SM Liu… - Science, 1996 - science.org
Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes,
and it has been proposed that these genes encode the ligand and receptor, respectively…

[HTML][HTML] Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

…, CE Lee, V Tang, CD Kenny, RA McGovern, SC Chua… - Neuron, 2004 - cell.com
Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC
neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of …

Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI

…, N Abate, BB Zhang, P Bonaldo, S Chua… - … and cellular biology, 2009 - Am Soc Microbiol
Adipocytes are embedded in a unique extracellular matrix whose main function is to provide
mechanical support, in addition to participating in a variety of signaling events. During …

[PDF][PDF] Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons

L Vong, C Ye, Z Yang, B Choi, S Chua, BB Lowell - Neuron, 2011 - cell.com
Leptin acts in the brain to prevent obesity. The underlying neurocircuitry responsible for this
is poorly understood, in part because of incomplete knowledge regarding first-order, leptin-…

[PDF][PDF] Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

…, R Coppari, N Balthasar, MA Cowley, S Chua… - Neuron, 2006 - cell.com
Leptin, an adipocyte-derived hormone, acts directly on the brain to control food intake and
energy expenditure. An important question is the identity of first-order neurons initiating …

[PDF][PDF] The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity

…, RA McGovern, V Tang, SM Liu, T Ludwig, SC Chua… - Cell metabolism, 2005 - cell.com
Leptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate
nucleus (ARH) has been proposed as an important site of leptin action. To assess the …

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

T Kitamura, Y Feng, Y Ido Kitamura, SC Chua Jr… - Nature medicine, 2006 - nature.com
Leptin controls food intake by regulating the transcription of key neuropeptides in the
hypothalamus. The mechanism by which leptin regulates gene expression is unclear, however. …

[HTML][HTML] Obesity, metabolic syndrome, and prostate cancer

AW Hsing, LC Sakoda, SC Chua Jr - The American journal of clinical …, 2007 - Elsevier
Although obesity has been consistently linked to an increased risk of several malignancies,
including cancers of the colon, gallbladder, kidney, and pancreas, its role in prostate cancer …

[HTML][HTML] Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

…, T Ludwig, SM Liu, SC Chua - The Journal of …, 2005 - Am Soc Clin Investig
We have generated mice that carry a neuron-specific leptin receptor (LEPR) transgene whose
expression is driven by the rat synapsin I promoter synapsin–LEPR B (SYN-LEPR-B). We …

[PDF][PDF] Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding

…, MA Faouzi, Y Gong, JC Jones, CJ Rhodes, S Chua… - Cell metabolism, 2009 - cell.com
The lateral hypothalamic area (LHA) acts in concert with the ventral tegmental area (VTA)
and other components of the mesolimbic dopamine (DA) system to control motivation, …