Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor
SC Chua Jr, WK Chung, XS Wu-Peng, Y Zhang, SM Liu… - Science, 1996 - science.org
Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes,
and it has been proposed that these genes encode the ligand and receptor, respectively…
and it has been proposed that these genes encode the ligand and receptor, respectively…
[HTML][HTML] Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
…, CE Lee, V Tang, CD Kenny, RA McGovern, SC Chua… - Neuron, 2004 - cell.com
Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC
neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of …
neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of …
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI
Adipocytes are embedded in a unique extracellular matrix whose main function is to provide
mechanical support, in addition to participating in a variety of signaling events. During …
mechanical support, in addition to participating in a variety of signaling events. During …
[PDF][PDF] Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
L Vong, C Ye, Z Yang, B Choi, S Chua, BB Lowell - Neuron, 2011 - cell.com
Leptin acts in the brain to prevent obesity. The underlying neurocircuitry responsible for this
is poorly understood, in part because of incomplete knowledge regarding first-order, leptin-…
is poorly understood, in part because of incomplete knowledge regarding first-order, leptin-…
[PDF][PDF] Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
Leptin, an adipocyte-derived hormone, acts directly on the brain to control food intake and
energy expenditure. An important question is the identity of first-order neurons initiating …
energy expenditure. An important question is the identity of first-order neurons initiating …
[PDF][PDF] The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity
…, RA McGovern, V Tang, SM Liu, T Ludwig, SC Chua… - Cell metabolism, 2005 - cell.com
Leptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate
nucleus (ARH) has been proposed as an important site of leptin action. To assess the …
nucleus (ARH) has been proposed as an important site of leptin action. To assess the …
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
T Kitamura, Y Feng, Y Ido Kitamura, SC Chua Jr… - Nature medicine, 2006 - nature.com
Leptin controls food intake by regulating the transcription of key neuropeptides in the
hypothalamus. The mechanism by which leptin regulates gene expression is unclear, however. …
hypothalamus. The mechanism by which leptin regulates gene expression is unclear, however. …
[HTML][HTML] Obesity, metabolic syndrome, and prostate cancer
AW Hsing, LC Sakoda, SC Chua Jr - The American journal of clinical …, 2007 - Elsevier
Although obesity has been consistently linked to an increased risk of several malignancies,
including cancers of the colon, gallbladder, kidney, and pancreas, its role in prostate cancer …
including cancers of the colon, gallbladder, kidney, and pancreas, its role in prostate cancer …
[HTML][HTML] Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
…, T Ludwig, SM Liu, SC Chua - The Journal of …, 2005 - Am Soc Clin Investig
We have generated mice that carry a neuron-specific leptin receptor (LEPR) transgene whose
expression is driven by the rat synapsin I promoter synapsin–LEPR B (SYN-LEPR-B). We …
expression is driven by the rat synapsin I promoter synapsin–LEPR B (SYN-LEPR-B). We …
[PDF][PDF] Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
…, MA Faouzi, Y Gong, JC Jones, CJ Rhodes, S Chua… - Cell metabolism, 2009 - cell.com
The lateral hypothalamic area (LHA) acts in concert with the ventral tegmental area (VTA)
and other components of the mesolimbic dopamine (DA) system to control motivation, …
and other components of the mesolimbic dopamine (DA) system to control motivation, …