Neuroprotective effect of (−) Δ9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite

AB El-Remessy, IE Khalil, S Matragoon… - The American journal of …, 2003 - Elsevier
In glaucoma, the increased release of glutamate is the major cause of retinal ganglion cell
death. Cannabinoids have been demonstrated to protect neuron cultures from glutamate-…

Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes

AS Ibrahim, AB El-Remessy, S Matragoon, W Zhang… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE During diabetes, retinal microglial cells are activated to release inflammatory
cytokines that initiate neuronal loss and blood–retinal barrier breakdown seen in diabetic …

[HTML][HTML] Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy

…, AB El-Remessy, G Ma, S Matragoon… - … & visual science, 2008 - arvojournals.org
purpose. Inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase (statins) reduce signs of
diabetic retinopathy in diabetic patients and animals. Indirect clinical evidence supports the …

Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes

TK Ali, S Matragoon, BA Pillai, GI Liou… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Recently we have shown that diabetes-induced retinal neurodegeneration
positively correlates with oxidative stress and peroxynitrite. Studies also show that peroxynitrite …

Thioredoxin interacting protein is a novel mediator of retinal inflammation and neurotoxicity

…, MA Abdelsaid, S Matragoon… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Up‐regulation of thioredoxin interacting protein (TXNIP),
an endogenous inhibitor of thioredoxin (Trx), compromises cellular antioxidant and anti‐…

Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene

GI Liou, Y Fei, NS Peachey, S Matragoon… - Journal of …, 1998 - Soc Neuroscience
Vision in all vertebrates is dependent on an exchange of retinoids between the retinal
pigment epithelium and the visual photoreceptors. It has been proposed that the …

[HTML][HTML] MicroRNA-146b-3p regulates retinal inflammation by suppressing adenosine deaminase-2 in diabetes

…, S Ahmad, R Sangani, S Matragoon… - BioMed research …, 2015 - hindawi.com
Hyperglycemia- (HG-) Amadori-glycated albumin- (AGA-) induced activation of microglia
and monocytes and their adherence to retinal vascular endothelial cells contribute to retinal …

[HTML][HTML] Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation

AB El-Remessy, HE Tawfik, S Matragoon… - Journal of Diabetes …, 2010 - hindawi.com
Endothelial dysfunction is characterized by reduced bioavailability of NO due to its inactivation
to form peroxynitrite or reduced expression of eNOS. Here, we examine the causal role of …

[HTML][HTML] Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation

AB El-Remessy, Y Tang, G Zhu, S Matragoon… - Molecular …, 2008 - ncbi.nlm.nih.gov
Purpose Degenerative retinal diseases are characterized by inflammation and microglial
activation. The nonpsychoactive cannabinoid, cannabidiol (CBD), is an anti-inflammatory in …

Simvastatin improves diabetes-induced coronary endothelial dysfunction

HE Tawfik, AB El-Remessy, S Matragoon, G Ma… - … of Pharmacology and …, 2006 - ASPET
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors decrease cardiovascular morbidity in
diabetic patients, but the mechanism is unclear. We studied the actions of simvastatin (SIM) in …