[PDF][PDF] The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging

IJ Cajigas, G Tushev, TJ Will, S tom Dieck, N Fuerst… - Neuron, 2012 - cell.com
In neurons, dendritic protein synthesis is required for many forms of long-term synaptic
plasticity. The population of mRNAs that are localized to dendrites, however, remains sparsely …

Hair cell synaptic ribbons are essential for synchronous auditory signalling

D Khimich, R Nouvian, R Pujol, S Tom Dieck, A Egner… - Nature, 2005 - nature.com
Hearing relies on faithful synaptic transmission at the ribbon synapse of cochlear inner hair
cells (IHCs) 1 , 2 , 3 . At present, the function of presynaptic ribbons at these synapses is still …

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

…, C Spilker, D Balschun, BV Skryabin, ST Dieck… - Nature, 2012 - nature.com
Autism spectrum disorders comprise a range of neurodevelopmental disorders characterized
by deficits in social interaction and communication, and by repetitive behaviour 1 . …

[HTML][HTML] The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina

O Dick, S tom Dieck, WD Altrock, J Ammermüller… - Neuron, 2003 - cell.com
The photoreceptor ribbon synapse is a highly specialized glutamatergic synapse designed
for the continuous flow of synaptic vesicles to the neurotransmitter release site. The …

Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex

S tom Dieck, WD Altrock, MM Kessels… - The Journal of cell …, 2005 - rupress.org
Susanne tom Diecktom Dieck and WD Altrock contributed equally to this paper. …
tom Dieck and WD Altrock contributed equally to this paper. …

[HTML][HTML] Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon

WD Altrock, S Tom Dieck, M Sokolov, AC Meyer… - Neuron, 2003 - cell.com
Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were
generated to establish the role of this protein in the assembly and function of active zones as …

Direct visualization of newly synthesized target proteins in situ

S tom Dieck, L Kochen, C Hanus, M Heumüller… - Nature …, 2015 - nature.com
Protein synthesis is a dynamic process that tunes the cellular proteome in response to
internal and external demands. Metabolic labeling approaches identify the general proteomic …

Local translation in neuronal compartments: how local is local?

V Rangaraju, S tom Dieck, EM Schuman - EMBO reports, 2017 - embopress.org
Efficient neuronal function depends on the continued modulation of the local neuronal proteome.
Local protein synthesis plays a central role in tuning the neuronal proteome at specific …

The translatome of neuronal cell bodies, dendrites, and axons

…, A Kao, I Bartnik, S tom Dieck… - Proceedings of the …, 2021 - National Acad Sciences
To form synaptic connections and store information, neurons continuously remodel their
proteomes. The impressive length of dendrites and axons imposes logistical challenges to …

Cell-type-specific metabolic labeling of nascent proteomes in vivo

…, C Hanus, C Glock, S tom Dieck… - Nature …, 2017 - nature.com
Although advances in protein labeling methods have made it possible to measure the proteome
of mixed cell populations, it has not been possible to isolate cell-type-specific proteomes …