Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor
receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these …

Maintenance of hematopoietic stem cells (HSCs) depends on interaction with their niche.
Here we show that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor, …

Neurons destined for the cerebral neocortex are formed in the pseudostratified ventricular
epithelium (PVE) lining the ventricular cavity of the developing cerebral wall. The present study…

Mutations in the epidermal growth factor receptor gene (EGFR) in lung cancers predict for
sensitivity to EGFR kinase inhibitors. HER2 (also known as NEU, EGFR2, or ERBB2) is a …

The NEURONS OF the neocortex arise from a pseudostratified ventricular epithelium (WE)
that lines the ventricular cavity of the mammalian embryonic cerebral wallle3. In any given …

Mollusc shells consist of the nacreous mother-of-pearl layer and the prismatic layer. Both
layers are microlaminate composites of CaCO 3 crystals (aragonite in the nacre and calcite in …

Cyclin-dependent kinase 5 (cdk5) was originally isolated on the basis of its close primary
sequence homology to the human cdc2 serine/threonine kinase, the prototype of the cyclin-…

Neurons of neocortical layers II–VI in the dorsomedial cortex of the mouse arise in the
pseudostratified ventricular epithelium (PVE) through 11 cell cycles over the six embryonic days 11…

PLK (polo‐like kinase), the human counterpart of polo in Drosophila melanogaster and of
CDC5 in Saccharomyces cerevisiae, belongs to a family of serine/threonine kinases. It is …

Neurons destined for each region of the neocortex are known to arise approximately in an “inside-to-outside”
sequence from a pseudostratified ventricular epithelium (PVE). This …