BACE1 activity is modulated by cell-associated sphingosine-1-phosphate

…, H Isshiki, Y Hori, N Shimada, T Higo… - Journal of …, 2011 - Soc Neuroscience
Sphingosine kinase (SphK) 1 and 2 phosphorylate sphingosine to generate sphingosine-1-phosphate
(S1P), a pluripotent lipophilic mediator implicated in a variety of cellular events. …

Phenylpiperidine‐type γ‐secretase modulators target the transmembrane domain 1 of presenilin 1

Y Ohki, T Higo, K Uemura, N Shimada, S Osawa… - The EMBO …, 2011 - embopress.org
Amyloid‐β peptide ending at the 42nd residue (Aβ42) is implicated in the pathogenesis of
Alzheimer's disease (AD). Small compounds that exhibit selective lowering effects on Aβ42 …

Expedient synthesis of core disaccharide building blocks from natural polysaccharides for heparan sulfate oligosaccharide assembly

NJ Pawar, L Wang, T Higo, C Bhattacharya… - Angewandte …, 2019 - Wiley Online Library
The complex sulfation motifs of heparan sulfate glycosaminoglycans (HS GAGs) play critical
roles in many important biological processes. However, an understanding of their specific …

[HTML][HTML] Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

…, N Shimada, A Tominaga, S Osawa, T Higo… - Molecular …, 2014 - Springer
Background Amyloid-β peptide ending at 42nd residue (Aβ42) is believed as a pathogenic
peptide for Alzheimer disease. Although γ-secretase is a responsible protease to generate …

Formal Synthesis of Sarain A: Intramolecular Cycloaddition of an Eight‐Membered Cyclic Nitrone to Construct the 2‐Azabicyclo [3.3. 1] nonane Framework

T Higo, T Ukegawa, S Yokoshima… - Angewandte …, 2015 - Wiley Online Library
An enantioselective route to the tetracyclic skeleton of sarain A has been developed.
Asymmetric reduction of an ynone introduced a chiral center which was transferred to the …

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition

…, S Osawa, N Shimada, T Higo… - Journal of Medicinal …, 2013 - ACS Publications
Substrate-selective inhibition or modulation of the activity of γ-secretase, which is responsible
for the generation of amyloid-β peptides, might be an effective strategy for prevention and …

Block BSS Method for Extracting Pulse Wave Under Noisy Environment

T Ogawa, T Higo, H Matsumoto - 2019 IEEE International …, 2019 - ieeexplore.ieee.org
A Blind Source Separation (BSS) can separate the source signals from only the observation
signals mixed the plural signals under the condition that the source signals and the mixing …

Premotor cortical-cerebellar reorganization in a macaque model of primary motor cortical lesion and recovery

…, T Hayashi, Y Murata, T Ose, N Higo - Journal of …, 2019 - Soc Neuroscience
Neuromotor systems have the capacity for functional recovery following local damage. The
literature suggests a possible role for the premotor cortex and cerebellum in motor recovery. …

Streamlined synthesis of core disaccharide building blocks from natural polysaccharides for the generation of heparan sulfate libraries

NJ Pawar, L Wang, T Higo… - … OF PAPERS OF …, 2019 - authors.library.caltech.edu
Heparan sulfate (HS) glycosaminoglycans (GAGs) are linear, diversely sulfated polysaccharides
that regulate a wide range of essential biol. processes, including growth factor signaling…

Room-temperature terahertz anomalous Hall effect in Weyl antiferromagnet Mn3Sn thin films

T Matsuda, T Higo, N Kanda, R Matsunaga - Oyo Buturi (Online), 2021 - inis.iaea.org
[en] Antiferromagnets are promising materials for realizing ultrafast spintronic devices because
their spin precession motions can be driven at terahertz frequencies. But the readout of …