User profiles for Tanaya Shree
 | Tanaya ShreeOregon Health & Sciences University Verified email at ohsu.edu Cited by 1931 |
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
Innate immune cells can constitute a substantial proportion of the cells within the tumor
microenvironment and have been associated with tumor malignancy in patients and animal …
microenvironment and have been associated with tumor malignancy in patients and animal …
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
The microenvironment is known to critically modulate tumor progression, yet its role in
regulating treatment response is poorly understood. Here we found increased macrophage …
regulating treatment response is poorly understood. Here we found increased macrophage …
Single-cell analysis can define distinct evolution of tumor sites in follicular lymphoma
Tumor heterogeneity complicates biomarker development and fosters drug resistance in
solid malignancies. In lymphoma, our knowledge of site-to-site heterogeneity and its clinical …
solid malignancies. In lymphoma, our knowledge of site-to-site heterogeneity and its clinical …
CD20-Targeted Therapy Ablates De Novo Antibody Response to Vaccination but Spares Preestablished Immunity
In a large cohort of patients with B-cell lymphoma, time since anti-CD20 treatment was an
independent predictor of neutralizing antibody response to COVID-19 vaccination. Comparing …
independent predictor of neutralizing antibody response to COVID-19 vaccination. Comparing …
Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine model of Parkinson's disease
Accumulating evidence suggests that apoptotic and inflammatory factors contribute to the
demise of dopaminergic neurons. In this respect, Fas, a member of the tumor necrosis factor …
demise of dopaminergic neurons. In this respect, Fas, a member of the tumor necrosis factor …
[HTML][HTML] PARP14 is a novel target in STAT6 mutant follicular lymphoma
The variable clinical course of follicular lymphoma (FL) is determined by the molecular
heterogeneity of tumor cells and complex interactions within the tumor microenvironment (TME). IL…
heterogeneity of tumor cells and complex interactions within the tumor microenvironment (TME). IL…
B-cell lymphomas present immunoglobulin neoantigens
Non-Hodgkin B-cell lymphomas are almost invariably derived from B lymphocytes that have
undergone productive V (D) J rearrangements of their immunoglobulin genes and may …
undergone productive V (D) J rearrangements of their immunoglobulin genes and may …
Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model
Proteolytic activity is required for several key processes in cancer development and progression,
including tumor growth, invasion and metastasis. Accordingly, high levels of protease …
including tumor growth, invasion and metastasis. Accordingly, high levels of protease …
Single-cell multi-gene identification of somatic mutations and gene rearrangements in cancer
In this proof-of-concept study, we developed a single-cell method that provides genotypes
of somatic alterations found in coding regions of messenger RNAs and integrates these …
of somatic alterations found in coding regions of messenger RNAs and integrates these …
[HTML][HTML] Impaired immune health in survivors of diffuse large B-cell lymphoma
PURPOSE Therapeutic advances for diffuse large B-cell lymphoma (DLBCL) have led to an
increasing number of survivors. Both DLBCL and its treatments perturb the immune system, …
increasing number of survivors. Both DLBCL and its treatments perturb the immune system, …