Misophonia is an affective sound-processing disorder characterized by the experience of
strong negative emotions (anger and anxiety) in response to everyday sounds, such as those …

Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with
about a third of cases being genetic. Most of this genetic component is accounted for by …

The ability to assess the distribution and extent of tau pathology in Alzheimer’s disease and
progressive supranuclear palsy in vivo would help to develop biomarkers for these …

Alzheimer’s disease and progressive supranuclear palsy (PSP) represent neurodegenerative
tauopathies with predominantly cortical versus subcortical disease burden. In Alzheimer’s …

Perception relies on the integration of sensory information and prior expectations. Here we
show that selective neurodegeneration of human frontal speech regions results in delayed …

The clinical syndromes of frontotemporal dementia are clinically and neuropathologically
heterogeneous, but processes such as neuroinflammation may be common across the disease …

Frontotemporal dementia is clinically and neuropathologically heterogeneous, but
neuroinflammation, atrophy and cognitive impairment occur in all of its principal syndromes. Across …

Introduction Semantic dementia, including the semantic variant of primary progressive
aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C …

The timing of perceptual events depends on an anatomically and functionally connected
network comprising basal ganglia, cerebellum, pre-frontal cortex and supplementary motor area…

Objective Synaptic loss is an early feature of neurodegenerative disease models, and is
severe in post mortem clinical studies, including frontotemporal dementia. Positron emission …