Experience-dependent maturation of neocortical circuits is required for normal sensory and
cognitive abilities, which are distorted in neurodevelopmental disorders. We tested whether …

Angelman syndrome (AS) is a severe neurodevelopmental disorder associated with disruption
of maternally inherited UBE3A (ubiquitin protein ligase E3A) expression. At the present …

The Aryl hydrocarbon Receptor(AhR) is among the most important receptors which bind
pollutants; however it also regulates signaling pathways independently of such exposure. We …

Primary open-angle glaucoma (POAG) is characterized by progressive neurodegeneration
of retinal ganglion cells (RGCs). Why RGCs degenerate in low-pressure POAG remains …

NrCAM is a neural cell adhesion molecule of the L1 family that has been linked to autism
spectrum disorders, a disease spectrum in which abnormal thalamocortical connectivity may …

Angelman syndrome (AS) is a neurodevelopmental disorder caused by maternal deletions
or mutations of the ubiquitin ligase E3A (UBE3A) allele and characterized by minimal verbal …

Background: Pleasure and reward are critical features of alcohol drinking that are difficult to
measure in animal studies. Intracranial self‐stimulation (ICSS) is a behavioral method for …

BACKGROUND: Substance abuse during pregnancy results in persistent affective and
behavioral deficits in drug-exposed children, and increased rates of substance abuse have been …

Repeated psychostimulant exposure progressively increases their potency to stimulate
motor activity in rodents. This behavioral or locomotor sensitization is considered a model for …

The orexin family of hypothalamic neuropeptides has been implicated in reinforcement
mechanisms relevant to both food and drug reward. Previous behavioral studies with antagonists …