Four Dlx homeobox genes, Dlx1,Dlx2, Dlx5, and Dlx6 are expressed in the same primordia
of the mouse forebrain with temporally overlapping patterns. The four genes are organized …

The expression of the Dlx homeobox genes is closely associated with neurons that express
γ-aminobutyric acid (GABA) in the embryonic rostral forebrain. To test whether the Dlx genes …

Despite therapeutic advances multiple myeloma remains largely incurable, and novel
therapeutic concepts are needed. The Hsp90-chaperone is a reasonable therapeutic target, …

The main factors that govern the pathophysiology and malignant growth of multiple myeloma
(MM) are genetic defects within the tumour and the interaction between myeloma cells and …

In this paper we analyse the expression pattern of a zebrafish dlx4/6 enhancer/reporter construct
in embryonic transgenic mice. We show that the pattern of LacZ/β-galactosidase in cells …

Current knowledge about molecular mechanisms underlying disease progression and drug
resistance in multiple myeloma (MM) is still limited. Here, we analyzed the potential …

Mutation of p53 is a rare event in multiple myeloma, but it is unknown if p53 signaling is
functional in myeloma cells, and if targeted nongenotoxic activation of the p53 pathway is …

The interleukin-6 receptor (IL-6R)/signal transducer and activator of transcription 3 (STAT3)
pathway contributes to the pathogenesis of multiple myeloma (MM) and protects MM cells …

The combined blockade of the IL-6R/STAT3 and the MAPK signaling pathways has been
shown to inhibit bone marrow microenvironment (BMM)–mediated survival of multiple …

Despite an increasing number of approved therapies, multiple myeloma (MM) remains an
incurable disease and only a small number of patients achieve prolonged disease control. …