The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the
clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a …

Neurons and glial cells exchange energy-rich metabolites and it has been suggested,
originally based on in vitro data, that astrocytes provide lactate to glutamatergic synapses (“lactate …

In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the
blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly …

Pelizaeus–Merzbacher disease (PMD) is an untreatable and fatal leukodystrophy. In a model
of PMD with perturbed blood–brain barrier integrity, cholesterol supplementation promotes …

To maintain homeostasis, the body, including the brain, reprograms its metabolism in response
to altered nutrition or disease. However, the consequences of these challenges for the …

Background: Studying astrocytes in higher brain functions has been hampered by the lack of
genetic tools for the efficient expression of inducible Cre recombinase throughout the CNS, …

Background Pharmaceutical intervention in the CNS is hampered by the shielding function
of the blood–brain barrier (BBB). To induce clinical anesthesia, general anesthetics such as …

Stromal cells support epithelial cell and immune cell homeostasis and play an important role
in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response …

Spatial biology is integral to understanding the dynamics of immune cells, tumor
microenvironment (TME), and therapeutic responses in cancer research. Ultra-high-plex …

First of all, I want to thank my supervisor Dr. Gesine Saher for the opportunity to work on this
project that really captured my interest. Furthermore, I want to thank her for continuous …