The cellular hallmarks of Parkinson’s disease (PD) are the loss of nigral dopaminergic
neurons and the formation of α-synuclein-enriched Lewy bodies and Lewy neurites in the …

Recombinant lentiviral vectors (rLV) are powerful tools for gene transfer to the central
nervous system (CNS) and hold great potential as a therapeutic gene therapy strategy for …

Adeno-associated virus (AAV) capsid modification enables the generation of recombinant
vectors with tailored properties and tropism. Most approaches to date depend on random …

The ability to make specific perturbations to biological molecules in a cell or organism is a
central experimental strategy in modern research biology. We have developed a general …

Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles.
However, vector doses needed to achieve therapeutic effect are high and some target tissues …

Overexpression of human α-synuclein (α-syn) using recombinant adeno-associated viral (rAAV)
vectors provides a novel tool to study neurodegenerative processes seen in Parkinson's …

Hematopoietic stem cells (HSCs) undergo a functional switch in neonatal mice hallmarked
by a decrease in self-renewing divisions and entry into quiescence. Here, we investigated …

We examined the transduction efficiency of different adeno-associated virus (AAV) capsid
serotypes encoding for green fluorescent protein (GFP) flanked by AAV2 inverted terminal …

In this work, we describe a License Plate Recognition (LPR) system designed around
convolutional neural networks (CNNs) trained on synthetic images to avoid collecting and …

Short-hairpin RNA (shRNA)–mediated gene knockdown is a powerful tool for targeted gene
silencing and an emerging novel therapeutic strategy. Recent publications, however, …