The cyclooxygenases COX-1 and COX-2 catalyze the first committed step of prostaglandin
synthesis from arachidonic acid. Previous studies in rodent stroke models have shown that …

BACKGROUND: Loss-of-function null mutations R501X and 2282del4 in the skin barrier
gene, filaggrin (FLG), represent the most replicated genetic risk factors for atopic dermatitis (AD)…

Epidemiological studies demonstrate that chronic use of nonsteroidal anti-inflammatory drugs
(NSAIDs) in normal aging populations reduces the risk of developing Alzheimer's disease (…

BACKGROUND: Asthma is a complex disease characterized by striking ethnic disparities
not explained entirely by environmental, social, cultural, or economic factors. Of the limited …

5. McDonald CJ, Tierney WM. Computer-stored medical records: their future role in medical
practice. JAMA 1988; 259: 3433-40. 6. Cutler DM, Feldman NE, Horwitz JR. US adoption of …

Cyclo‐oxygenases (COXs) catalyze the first committed step in the synthesis of the
prostaglandins PGE 2 , PGD 2 , PGF 2α , PGI 2 and thomboxane A 2 . Expression and enzymatic …

Increases in COX‐2 enzymatic activity and prostaglandin production have been associated
with neuronal injury in both acute and age‐related degenerative neurological diseases. In …

Nitric oxide (NO) acts as a neurotransmitter. However, excess NO produced from neuronal
NO synthase (nNOS) or inducible NOS (iNOS) during inflammation of the central nervous …

Although the integral membrane proteins that catalyze steps in the biosynthesis of
neuroendocrine peptides are known to contain routing information in their cytosolic domains, the …

Long-chain polyunsaturated fatty acids (PUFA) orchestrate immunity and inflammation
through their capacity to be converted to potent inflammatory mediators. We assessed …