User profiles for Tracy L. Bale

Tracy Bale

University of Colorado, Anschutz Medical Campus, Dept of Psychiatry
Verified email at cuanschutz.edu
Cited by 21736

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

TL Bale, A Contarino, GW Smith, R Chan, LH Gold… - Nature …, 2000 - nature.com
Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal
(HPA) axis. In response to stress, Crh released from the paraventricular nucleus (…

Early life programming and neurodevelopmental disorders

TL Bale, TZ Baram, AS Brown, JM Goldstein, TR Insel… - Biological …, 2010 - Elsevier
For more than a century, clinical investigators have focused on early life as a source of adult
psychopathology. Early theories about psychic conflict and toxic parenting have been …

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

…, CP Morgan, NA Leu, TL Bale - Proceedings of the …, 2015 - National Acad Sciences
Epigenetic signatures in germ cells, capable of both responding to the parental environment
and shaping offspring neurodevelopment, are uniquely positioned to mediate …

Sex differences and stress across the lifespan

TL Bale, CN Epperson - Nature neuroscience, 2015 - nature.com
Sex differences in stress responses can be found at all stages of life and are related to both
the organizational and activational effects of gonadal hormones and to genes on the sex …

Epigenetic and transgenerational reprogramming of brain development

TL Bale - Nature Reviews Neuroscience, 2015 - nature.com
Neurodevelopmental programming — the implementation of the genetic and epigenetic
blueprints that guide and coordinate normal brain development — requires tight regulation of …

CRF and CRF receptors: role in stress responsivity and other behaviors

TL Bale, WW Vale - Annu. Rev. Pharmacol. Toxicol., 2004 - annualreviews.org
Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands
and receptors has evolved. The mammalian family members include CRF, urocortinI (UcnI), …

Sex-specific programming of offspring emotionality after stress early in pregnancy

BR Mueller, TL Bale - Journal of Neuroscience, 2008 - Soc Neuroscience
Prenatal stress is associated with an increased vulnerability to neurodevelopmental disorders,
including autism and schizophrenia. To determine the critical time window when fetal …

Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation

…, SL Bronson, S Revello, TL Bale - Journal of …, 2013 - Soc Neuroscience
Neuropsychiatric disease frequently presents with an underlying hyporeactivity or
hyperreactivity of the HPA stress axis, suggesting an exceptional vulnerability of this circuitry to …

CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior

TL Bale, AM Davis, AP Auger, DM Dorsa… - Journal of …, 2001 - Soc Neuroscience
The oxytocin receptor (OTR) is differentially expressed in the CNS. Because there are multiple
mechanisms by which the OTR can be transcriptionally induced, we hypothesized that …

The epigenetics of sex differences in the brain

MM McCarthy, AP Auger, TL Bale… - Journal of …, 2009 - Soc Neuroscience
Epigenetic changes in the nervous system are emerging as a critical component of enduring
effects induced by early life experience, hormonal exposure, trauma and injury, or learning …