Vesicular release of ATP at central synapses

Y Pankratov, U Lalo, A Verkhratsky, RA North - Pflügers Archiv, 2006 - Springer
Adenosine triphosphate (ATP) acts as a fast excitatory transmitter in several regions of the
central nervous system (CNS) including the medial habenula, dorsal horn, locus coeruleus, …

P2X receptors and synaptic plasticity

Y Pankratov, U Lalo, OA Krishtal, A Verkhratsky - Neuroscience, 2009 - Elsevier
Adenosine triphosphate (ATP) is released in many synapses in the CNS either together with
other neurotransmitters, such as glutamate and GABA, or on its own. Postsynaptic action of …

The tripartite glutamatergic synapse

U Lalo, W Koh, CJ Lee, Y Pankratov - Neuropharmacology, 2021 - Elsevier
Astroglial cells were long considered as structural and metabolic supporting cells are which
do not directly participate in information processing in the brain. Discoveries of …

NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes

U Lalo, Y Pankratov, F Kirchhoff, RA North… - Journal of …, 2006 - Soc Neuroscience
Chemical transmission between neurons and glial cells is an important element of integration
in the CNS. Here, we describe currents activated by NMDA in cortical astrocytes, identified …

[HTML][HTML] Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex

U Lalo, O Palygin, S Rasooli-Nejad, J Andrew… - PLoS …, 2014 - journals.plos.org
Communication between neuronal and glial cells is important for many brain functions.
Astrocytes can modulate synaptic strength via Ca 2+ -stimulated release of various …

Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes

O Palygin, U Lalo, A Verkhratsky, Y Pankratov - Cell calcium, 2010 - Elsevier
Local, global and propagating calcium (Ca 2+ ) signals provide the substrate for glial
excitability. Here we analyse Ca 2+ permeability of NMDA and P2X 1/5 receptors expressed in …

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes

U Lalo, Y Pankratov, SP Wichert… - Journal of …, 2008 - Soc Neuroscience
ATP plays an important role in signal transduction between neuronal and glial circuits and
within glial networks. Here we describe currents activated by ATP in astrocytes acutely …

Role for P2X receptors in long-term potentiation

YV Pankratov, UV Lalo, OA Krishtal - Journal of Neuroscience, 2002 - Soc Neuroscience
ATP receptors participate in synaptic transmission and intracellular calcium signaling in the
hippocampus by providing a component of the excitatory input to CA1 pyramidal neurons. …

Quantal release of ATP in mouse cortex

Y Pankratov, U Lalo, A Verkhratsky… - The Journal of general …, 2007 - rupress.org
Transient currents occur at rest in cortical neurones that reflect the quantal release of
transmitters such as glutamate and γ-aminobutyric acid (GABA). We found a bimodal amplitude …

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

O Palygin, U Lalo, Y Pankratov - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Astrocytes of the mouse neocortex express functional NMDA
receptors, which are not blocked by Mg 2+ ions. However, the pharmacological profile of …