Vesicular release of ATP at central synapses
Adenosine triphosphate (ATP) acts as a fast excitatory transmitter in several regions of the
central nervous system (CNS) including the medial habenula, dorsal horn, locus coeruleus, …
central nervous system (CNS) including the medial habenula, dorsal horn, locus coeruleus, …
P2X receptors and synaptic plasticity
Adenosine triphosphate (ATP) is released in many synapses in the CNS either together with
other neurotransmitters, such as glutamate and GABA, or on its own. Postsynaptic action of …
other neurotransmitters, such as glutamate and GABA, or on its own. Postsynaptic action of …
The tripartite glutamatergic synapse
Astroglial cells were long considered as structural and metabolic supporting cells are which
do not directly participate in information processing in the brain. Discoveries of …
do not directly participate in information processing in the brain. Discoveries of …
NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes
Chemical transmission between neurons and glial cells is an important element of integration
in the CNS. Here, we describe currents activated by NMDA in cortical astrocytes, identified …
in the CNS. Here, we describe currents activated by NMDA in cortical astrocytes, identified …
[HTML][HTML] Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex
U Lalo, O Palygin, S Rasooli-Nejad, J Andrew… - PLoS …, 2014 - journals.plos.org
Communication between neuronal and glial cells is important for many brain functions.
Astrocytes can modulate synaptic strength via Ca 2+ -stimulated release of various …
Astrocytes can modulate synaptic strength via Ca 2+ -stimulated release of various …
Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes
Local, global and propagating calcium (Ca 2+ ) signals provide the substrate for glial
excitability. Here we analyse Ca 2+ permeability of NMDA and P2X 1/5 receptors expressed in …
excitability. Here we analyse Ca 2+ permeability of NMDA and P2X 1/5 receptors expressed in …
P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes
U Lalo, Y Pankratov, SP Wichert… - Journal of …, 2008 - Soc Neuroscience
ATP plays an important role in signal transduction between neuronal and glial circuits and
within glial networks. Here we describe currents activated by ATP in astrocytes acutely …
within glial networks. Here we describe currents activated by ATP in astrocytes acutely …
Role for P2X receptors in long-term potentiation
YV Pankratov, UV Lalo, OA Krishtal - Journal of Neuroscience, 2002 - Soc Neuroscience
ATP receptors participate in synaptic transmission and intracellular calcium signaling in the
hippocampus by providing a component of the excitatory input to CA1 pyramidal neurons. …
hippocampus by providing a component of the excitatory input to CA1 pyramidal neurons. …
Quantal release of ATP in mouse cortex
Y Pankratov, U Lalo, A Verkhratsky… - The Journal of general …, 2007 - rupress.org
Transient currents occur at rest in cortical neurones that reflect the quantal release of
transmitters such as glutamate and γ-aminobutyric acid (GABA). We found a bimodal amplitude …
transmitters such as glutamate and γ-aminobutyric acid (GABA). We found a bimodal amplitude …
Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes
O Palygin, U Lalo, Y Pankratov - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Astrocytes of the mouse neocortex express functional NMDA
receptors, which are not blocked by Mg 2+ ions. However, the pharmacological profile of …
receptors, which are not blocked by Mg 2+ ions. However, the pharmacological profile of …