Microglia: active sensor and versatile effector cells in the normal and pathologic brain

UK Hanisch, H Kettenmann - Nature neuroscience, 2007 - nature.com
Microglial cells constitute the resident macrophage population of the CNS. Recent in vivo
studies have shown that microglia carry out active tissue scanning, which challenges the …

Physiology of microglia

H Kettenmann, UK Hanisch, M Noda… - Physiological …, 2011 - journals.physiology.org
Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system, …

Microglia as a source and target of cytokines

UK Hanisch - Glia, 2002 - Wiley Online Library
Cytokines constitute a significant portion of the immuno‐ and neuromodulatory messengers
that can be released by activated microglia. By virtue of potent effects on resident and …

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

…, H Schmidt, M Nitsche, D Merkler, UK Hanisch… - Nature …, 2007 - nature.com
Microglia are crucially important myeloid cells in the CNS and constitute the first immunological
barrier against pathogens and environmental insults. The factors controlling microglia …

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

…, P Dibaj, M Bakhti, T Regen, UK Hanisch… - Journal of cell …, 2011 - journals.biologists.com
The transfer of antigens from oligodendrocytes to immune cells has been implicated in the
pathogenesis of autoimmune diseases. Here, we show that oligodendrocytes secrete small …

Cell type–and brain region–resolved mouse brain proteome

…, K Kongi, L Cantuti, UK Hanisch… - Nature …, 2015 - nature.com
Brain transcriptome and connectome maps are being generated, but an equivalent effort on
the proteome is currently lacking. We performed high-resolution mass spectrometry–based …

Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors

D Van Rossum, UK Hanisch, R QUIRION - Neuroscience & Biobehavioral …, 1997 - Elsevier
VAN ROSSUM, DU-K. HANISCH AND R. QUIRION. Neuroanatomical localization,
pharmacological characterization and functions of CGRP, related peptides and their receptors. …

GFAP promoter‐controlled EGFP‐expressing transgenic mice: a tool to visualize astrocytes and astrogliosis in living brain tissue

…, T Pivneva, CG Schipke, C Ohlemeyer, UK Hanisch… - Glia, 2001 - Wiley Online Library
We have generated transgenic mice in which astrocytes are labeled by the enhanced green
fluorescent protein (EGFP) under the control of the human glial fibrillary acidic protein (GFAP…

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

…, J Walter, F Kirchhoff, UK Hanisch… - Proceedings of the …, 2010 - National Acad Sciences
Locus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the
brain. To elucidate the effect of LC degeneration and subsequent NE deficiency on Alzheimer's …

Microglial phenotype: is the commitment reversible?

M Schwartz, O Butovsky, W Brück, UK Hanisch - Trends in neurosciences, 2006 - cell.com
Microglia, the standby cells for immune defense in the CNS, have a reputation for exacerbating
the neural damage that occurs in neurodegenerative diseases. However, research over …